Allergen-specific IgE, IgG, and Th2-type Cytokine Responses are Effectively Downregulated by Immunotherapy with the Novel Dendritic Cell (DC)-Stimulating Antibody, B7-DCXAb

Allergen-specific IgE, IgG, and Th2-type Cytokine Responses are Effectively Downregulated by Immunotherapy with the Novel Dendritic Cell (DC)-Stimulating Antibody, B7-DCXAb

Mice were sensitized by intraperitoneal injection of OVA or house dust mite (HDM) antigens plus alum and then treated by intravenous B7-DCXAb injection plus subcutaneous, intranasal or sublingual administration of antigen.

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Veröffentlicht in:Journal of allergy and clinical immunology 2009-03, Vol.123 (3), p.724-724
Hauptverfasser: Kita, H, Checkel, J.L, Iijima, K, Radhakrishnan, S, Van Keulen, V.P, Mcclimon, B.J, Kobayashi, T, Plager, D.A, Pease, L.R
Format: Artikel
Sprache:eng
Schlagworte:
Allergies
Allergy and Immunology
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Beschreibung
Zusammenfassung:Mice were sensitized by intraperitoneal injection of OVA or house dust mite (HDM) antigens plus alum and then treated by intravenous B7-DCXAb injection plus subcutaneous, intranasal or sublingual administration of antigen.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.01.006