Renal iron deposition by magnetic resonance imaging in pediatric β-thalassemia major patients: Relation to renal biomarkers, total body iron and chelation therapy

•Kidney iron deposition impairs renal glomerular and tubular functions in β-TM.•Renal R2*was higher in patients with poor compliance to chelation therapy.•Renal T2* cutoff

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Bibliographische Detailangaben
Veröffentlicht in:	European journal of radiology 2018-06, Vol.103, p.65-70
Hauptverfasser:	ElAlfy, Mohsen Saleh, Khalil Elsherif, Nayera Hazaa, Ebeid, Fatma Soliman Elsayed, Ismail, Eman Abdel Rahman, Ahmed, Khaled Aboulfotouh, Darwish, Yasser Wagih, Ibrahim, Ahmed Samir, Elghamry, Islam Reda Farag, Shokrey, Nermeen Adel, Alajeil, Dunia Naser
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Thalassemia - diagnostic imaging beta-Thalassemia - metabolism Biomarkers - metabolism Chelation Therapy - methods Child Cross-Sectional Studies Cystatin C Female Humans Iron - metabolism Iron Overload - diagnostic imaging Iron Overload - metabolism Iron Overload - therapy Liver - diagnostic imaging Liver - metabolism Magnetic Resonance Imaging - methods Male Renal R2 Tissue iron overload β-Thalassemia major β2-Microglobulin
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Beschreibung
Zusammenfassung:	•Kidney iron deposition impairs renal glomerular and tubular functions in β-TM.•Renal R2was higher in patients with poor compliance to chelation therapy.•Renal T2 cutoff
ISSN:	0720-048X 1872-7727
DOI:	10.1016/j.ejrad.2018.04.007