Telomere dysfunction and inactivation of the p16 super(INK4a)/Rb pathway in pyothorax-associated lymphoma

Telomere dysfunction and inactivation of the p16 super(INK4a)/Rb pathway in pyothorax-associated lymphoma

Previous studies have indicated that genome instability is involved in the lymphomagenesis of pyothorax-associated lymphoma (PAL), which develops in patients with a long-standing history of pyothorax. One of the well-known causes of genome instability is telomere dysfunction. In the present study, t...

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Veröffentlicht in:Cancer science 2007-07, Vol.98 (7), p.978-984
Hauptverfasser: Tresnasari, Kristianti, Takakuwa, Tetsuya, Ham, Maria Francisca, Rahadiani, Nur, Nakajima, Hiroo, Aozasa, Katsuyuki
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container_end_page 984
container_issue 7
container_start_page 978
container_title Cancer science
container_volume 98
creator Tresnasari, Kristianti
Takakuwa, Tetsuya
Ham, Maria Francisca
Rahadiani, Nur
Nakajima, Hiroo
Aozasa, Katsuyuki
description Previous studies have indicated that genome instability is involved in the lymphomagenesis of pyothorax-associated lymphoma (PAL), which develops in patients with a long-standing history of pyothorax. One of the well-known causes of genome instability is telomere dysfunction. In the present study, the condition of telomeres was analyzed in the cell lines and clinical samples from PAL. Telomere length (TL) in PAL cell lines was extremely short (
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One of the well-known causes of genome instability is telomere dysfunction. In the present study, the condition of telomeres was analyzed in the cell lines and clinical samples from PAL. Telomere length (TL) in PAL cell lines was extremely short (&lt;4.5 kbp). TL in tumor samples was broad in range, and shorter than that in the peripheral blood leukocytes from the matched patients. Three of five PAL cell lines showed frequent loss of telomere signals (telomere erosion); however, telomerase activity in PAL cell lines was similar to that in Burkitt lymphoma cell lines. Rb expression was detected in three PAL cell lines and four of 15 clinical samples, respectively. Rb protein expressed in three PAL cell lines was heavily phosphorylated, indicating that function of Rb protein was suppressed. p16 super(INK4a) expression was not detected in either cell lines or clinical samples. The promoter region in p16 super(INK4a) was heavily methylated in all cell lines as well as the clinical samples. Inactivation of the p16 super(INK4a)/Rb pathway may allow continuous cell division and critical telomere shortening, which induce genome instability, finally leading to malignant transformation. Taken together, telomere dysfunction and inactivation of the p16 super(INK4a)/Rb pathway might play a role for PAL development. 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title Telomere dysfunction and inactivation of the p16 super(INK4a)/Rb pathway in pyothorax-associated lymphoma
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