Telomere dysfunction and inactivation of the p16 super(INK4a)/Rb pathway in pyothorax-associated lymphoma
Previous studies have indicated that genome instability is involved in the lymphomagenesis of pyothorax-associated lymphoma (PAL), which develops in patients with a long-standing history of pyothorax. One of the well-known causes of genome instability is telomere dysfunction. In the present study, t...
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| Veröffentlicht in: | Cancer science 2007-07, Vol.98 (7), p.978-984 |
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| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Previous studies have indicated that genome instability is involved in the lymphomagenesis of pyothorax-associated lymphoma (PAL), which develops in patients with a long-standing history of pyothorax. One of the well-known causes of genome instability is telomere dysfunction. In the present study, the condition of telomeres was analyzed in the cell lines and clinical samples from PAL. Telomere length (TL) in PAL cell lines was extremely short ( |
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| ISSN: | 1347-9032 1349-7006 |
| DOI: | 10.1111/j.1349-7006.2007.00482.x |