Daily oral 25-hydroxycholecalciferol supplementation for vitamin D deficiency in haemodialysis patients: effects on mineral metabolism and bone markers

Background. Vitamin D deficiency is frequently observed in end-stage renal disease (ESRD) patients; however, the effects of vitamin D supplementation have rarely been reported. We aimed to assess the effects of daily 25(OH)D3 supplementation on mineral metabolism, bone markers and Kidney Disease Out...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2008-11, Vol.23 (11), p.3670-3676
Hauptverfasser:	Jean, Guillaume, Terrat, Jean-Claude, Vanel, Thierry, Hurot, Jean-Marc, Lorriaux, Christie, Mayor, Brice, Chazot, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	25-hydroxyvitamin D Administration, Oral Aged Aged, 80 and over Alkaline Phosphatase - metabolism Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biomarkers - metabolism Bone and Bones - metabolism Bone Density Conservation Agents - therapeutic use bone markers Calcifediol - administration & dosage Calcifediol - therapeutic use Calcium - blood Dietary Supplements Dose-Response Relationship, Drug Emergency and intensive care: renal failure. Dialysis management Female General and cellular metabolism. Vitamins haemodialysis Humans Hydroxycholecalciferols - therapeutic use Intensive care medicine Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy Male Medical sciences Middle Aged mineral metabolism Outcome Assessment (Health Care) Pharmacology. Drug treatments Phosphorus - blood Renal Dialysis Vitamin D - administration & dosage Vitamin D - therapeutic use vitamin D deficiency Vitamin D Deficiency - drug therapy Vitamin D Deficiency - metabolism
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Zusammenfassung:	Background. Vitamin D deficiency is frequently observed in end-stage renal disease (ESRD) patients; however, the effects of vitamin D supplementation have rarely been reported. We aimed to assess the effects of daily 25(OH)D3 supplementation on mineral metabolism, bone markers and Kidney Disease Outcomes Quality Initiative (KDOQI) targets in haemodialysis (HD) patients for a period of 6 months. Methods. HD patients were included in this study if their serum 25(OH)D level was
ISSN:	0931-0509 1460-2385
DOI:	10.1093/ndt/gfn339