Increased Intratumor V alpha 24-Positive Natural Killer T Cells: A Prognostic Factor for Primary Colorectal Carcinomas

Increased Intratumor V alpha 24-Positive Natural Killer T Cells: A Prognostic Factor for Primary Colorectal Carcinomas

PURPOSE: Human invariant natural killer T (NKT) cells are novel, distinct lymphocyte populations with a restricted T-cell receptor repertoire (V alpha 24-V beta 11). They play a pivotal role in immunoregulation and in antitumor activities. This study focused on V alpha 24 super(+) NKT cells in color...

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Veröffentlicht in:Clinical cancer research 2005-10, Vol.11 (20), p.7322-7327
Hauptverfasser: Tachibana, Tsuyoshi, Onodera, Hisashi, Tsuruyama, Tatsuaki, Mori, Akira, Nagayama, Satoshi, Hiai, Hiroshi, Imamura, Masayuki
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Sprache:eng
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Zusammenfassung:PURPOSE: Human invariant natural killer T (NKT) cells are novel, distinct lymphocyte populations with a restricted T-cell receptor repertoire (V alpha 24-V beta 11). They play a pivotal role in immunoregulation and in antitumor activities. This study focused on V alpha 24 super(+) NKT cells in colorectal carcinomas and their clinicopathologic significance. Experimental Design: V alpha 24 super(+) NKT-cell infiltration immunohistochemistry was studied in a total of 103 colorectal carcinoma cases. The degree of NKT-cell infiltration in tumors was evaluated as low (
ISSN:1078-0432
DOI:10.1158/1078-0432.CCR-05-0877