Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF- mu B

Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF- mu B

Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF- mu B (nuclear factor- mu B) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparabl...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2009-03, Vol.19 (6), p.1726-1728
Hauptverfasser: Ishikawa, Yuichi, Tachibana, Miyuki, Matsui, Chino, Obata, Rika, Umezawa, Kazuo, Nishiyama, Shigeru
Format: Artikel
Sprache:eng
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Zusammenfassung:Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF- mu B (nuclear factor- mu B) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity against LPS-induced NO production comparable to that of 9-methylstreptimidone.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2009.01.107