Neurodevelopment of breastfed HIV-exposed uninfected and HIV-unexposed children in South Africa

Neurodevelopment of breastfed HIV-exposed uninfected and HIV-unexposed children in South Africa

OBJECTIVES:To assess neurodevelopment of breastfed HIV-exposed uninfected (HEU) and breastfed HIV-unexposed children in the context of universal maternal antiretroviral therapy (ART). DESIGN:Prospective study with antenatal enrolment and follow-up of breastfeeding HEU and HIV-unexposed mother–infant...

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Veröffentlicht in:AIDS (London) 2018-08, Vol.32 (13), p.1781-1791
Hauptverfasser: le Roux, Stanzi M, Donald, Kirsten A, Brittain, Kirsty, Phillips, Tamsin K, Zerbe, Allison, Nguyen, Kelly K, Strandvik, Andrea, Kroon, Max, Abrams, Elaine J, Myer, Landon
Format: Artikel
Sprache:eng
Schlagworte:
Adult
AIDS/HIV
Breast Feeding
Child Development
Environmental Exposure
Female
Follow-Up Studies
HIV Infections - drug therapy
Humans
Incidence
Infant
Infant, Newborn
Male
Neurodevelopmental Disorders - epidemiology
Pregnancy
Prospective Studies
South Africa
Young Adult
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Zusammenfassung:OBJECTIVES:To assess neurodevelopment of breastfed HIV-exposed uninfected (HEU) and breastfed HIV-unexposed children in the context of universal maternal antiretroviral therapy (ART). DESIGN:Prospective study with antenatal enrolment and follow-up of breastfeeding HEU and HIV-unexposed mother–infant pairs through 12–18 months postpartum. SETTING:Peri-urban community, Cape Town, South Africa. PARTICIPANTS:HEU (n = 215) and HIV-unexposed (n = 306) children. MAIN OUTCOME MEASURES:Cognitive, motor and language development at median 13 (interquartile range 12–14) months of agecontinuous and dichotomous Bayley Scales of Infant and Toddler Development Third Edition (delay defined as composite score
ISSN:0269-9370
1473-5571
DOI:10.1097/QAD.0000000000001872