New Fluorescent Reporter Systems for Evaluation of the Expression of E- and N-Cadherins
During metastatic growth, cells of solid tumors undergo phenotypical changes related to epithelial-mesenchymal transition. Epithelial-mesenchymal transition is regarded as a potential target for prospective antitumor drugs. Fluorescent reporter systems for evaluation of the expression of markers of...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2018-05, Vol.165 (1), p.88-93 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Burmistrova, O. A. Nikulin, S. V. Zakharova, G. S. Fomicheva, K. A. Alekseev, B. Ya Shkurnikov, M. Yu |
| description | During metastatic growth, cells of solid tumors undergo phenotypical changes related to epithelial-mesenchymal transition. Epithelial-mesenchymal transition is regarded as a potential target for prospective antitumor drugs. Fluorescent reporter systems for evaluation of the expression of markers of epithelial and mesenchymal status (E- and N-cadherins) were created. The described approaches can be used for creation of analogous reporter systems. |
| doi_str_mv | 10.1007/s10517-018-4106-x |
| format | Article |
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A.</creatorcontrib><creatorcontrib>Alekseev, B. Ya</creatorcontrib><creatorcontrib>Shkurnikov, M. Yu</creatorcontrib><title>New Fluorescent Reporter Systems for Evaluation of the Expression of E- and N-Cadherins</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>During metastatic growth, cells of solid tumors undergo phenotypical changes related to epithelial-mesenchymal transition. Epithelial-mesenchymal transition is regarded as a potential target for prospective antitumor drugs. Fluorescent reporter systems for evaluation of the expression of markers of epithelial and mesenchymal status (E- and N-cadherins) were created. The described approaches can be used for creation of analogous reporter systems.</description><subject>Analysis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cadherins - genetics</subject><subject>Cadherins - metabolism</subject><subject>Cancer metastasis</subject><subject>Cell Biology</subject><subject>Cell Line, Tumor</subject><subject>Epithelial-Mesenchymal Transition - drug effects</subject><subject>Epithelial-Mesenchymal Transition - genetics</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Mesenchyme</subject><subject>Metastases</subject><subject>Pathology</subject><subject>Phenotypes</subject><subject>Prospective Studies</subject><subject>Solid tumors</subject><subject>Stem cells</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kV1vFCEYhYnR2LX6A7wxJCbGG1pgYGAum81WTZqaVI2XhJ156U4zAyswuv33Mtm1H0bDBeHlOSccDkKvGT1hlKrTxKhkilCmiWC0JrsnaMGkqojmnD1FC1ogIrTWR-hFSjfzkdbsOTrijWoUq6oF-n4Jv_D5MIUIqQWf8RVsQ8wQ8ZfblGFM2IWIVz_tMNncB4-Dw3kDeLXbFkU6TFYEW9_hS7K03QZi79NL9MzZIcGrw36Mvp2vvi4_kovPHz4tzy5IKzjPRHeiXoPQtVSi4U5SrYVad5a7BhrXUWcb0dSykaKi2oJTsnayVa10De8019Uxer_33cbwY4KUzdiXIMNgPYQpGU6F5KrSbEbf_oXehCn68rqZqiRjlNF76toOYHrvQo62nU3NmRSiUFLUhTr5B1VWB2PfBg-uL_NHgncPBBuwQ96kMEzzn6bHINuDbQwpRXBmG_vRxlvDqJlbN_vWTWndzK2bXdG8OSSb1iN0d4o_NReA74FUrvw1xPvo_3f9Dd73s58</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Burmistrova, O. 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| subjects | Analysis Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Cadherins - genetics Cadherins - metabolism Cancer metastasis Cell Biology Cell Line, Tumor Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Humans Internal Medicine Laboratory Medicine Mesenchyme Metastases Pathology Phenotypes Prospective Studies Solid tumors Stem cells |
| title | New Fluorescent Reporter Systems for Evaluation of the Expression of E- and N-Cadherins |
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