New Fluorescent Reporter Systems for Evaluation of the Expression of E- and N-Cadherins

During metastatic growth, cells of solid tumors undergo phenotypical changes related to epithelial-mesenchymal transition. Epithelial-mesenchymal transition is regarded as a potential target for prospective antitumor drugs. Fluorescent reporter systems for evaluation of the expression of markers of...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2018-05, Vol.165 (1), p.88-93
Hauptverfasser:	Burmistrova, O. A., Nikulin, S. V., Zakharova, G. S., Fomicheva, K. A., Alekseev, B. Ya, Shkurnikov, M. Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Cadherins - genetics Cadherins - metabolism Cancer metastasis Cell Biology Cell Line, Tumor Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Humans Internal Medicine Laboratory Medicine Mesenchyme Metastases Pathology Phenotypes Prospective Studies Solid tumors Stem cells
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Zusammenfassung:	During metastatic growth, cells of solid tumors undergo phenotypical changes related to epithelial-mesenchymal transition. Epithelial-mesenchymal transition is regarded as a potential target for prospective antitumor drugs. Fluorescent reporter systems for evaluation of the expression of markers of epithelial and mesenchymal status (E- and N-cadherins) were created. The described approaches can be used for creation of analogous reporter systems.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-018-4106-x