Loss of Heterozygosity in BRCA1 and BRCA2 Genes in Patients with Ovarian Cancer and Probability of Its Use for Clinical Classification of Variations

Changes (or variants) in BRCA1 and BRCA2 gene sequences can have different lengths and clinical significance: from single nucleotide variants (SNV) and short insertions/deletions (

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Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2018-05, Vol.165 (1), p.94-100
Hauptverfasser:	Kechin, A. A., Boyarskikh, U. A., Ermolenko, N. A., Tyulyandina, A. S., Lazareva, D. G., Avdalyan, A. M., Tyulyandin, S. A., Kushlinskii, N. E., Filipenko, M. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Benign Biomedical and Life Sciences Biomedicine Blood cells BRCA1 protein BRCA1 Protein - genetics BRCA2 protein BRCA2 Protein - genetics Breast Neoplasms - genetics Cancer genetics Cancer patients Cancer research Carcinogenesis Cell Biology Copy number Deoxyribonucleic acid DNA DNA Copy Number Variations - genetics Exons Exons - genetics Female Gene conversion Genes Genetic aspects Genetic Predisposition to Disease - genetics Heterozygosity Humans Internal Medicine Laboratory Medicine Loss of heterozygosity Loss of Heterozygosity - genetics Nucleotide sequence Ovarian cancer Ovarian Neoplasms - genetics Pathology
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Beschreibung
Zusammenfassung:	Changes (or variants) in BRCA1 and BRCA2 gene sequences can have different lengths and clinical significance: from single nucleotide variants (SNV) and short insertions/deletions (
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-018-4107-9