Out-of-body experience in the anterior insular cortex during the intracranial electrodes stimulation in an epileptic child

•An epileptic child stimulated to occur out-of-body experience in the anterior insular.•Out-of-body experience mostly occurred in the temporo-parietal junction.•Seizure free and out-of-body experience disappeared after the operation.•Disorder of intergration and self-consciousness lead to the out-of-body experience. The authors present a case of an out-of- body experience (OBE) that occurred in a child with intractable epilepsy when stimulating the anterior insular cortex (AIC) by intracranial electrodes. After destroying several sites precisely located at the left AIC by radiofrequency thermocoagulation, the patient’s seizures disappeared, and the OBE could not be reproduced when repeatedly stimulating these sites. To our knowledge, it has never been reported that an OBE occurred in the AIC. We analyze the mechanism of an OBE mostly appearing in temporo-parietal junction (TPJ) and propose two perspectives for a possible mechanism involving the AIC causing the OBE.