Analysis of Blood Plasma Protein Composition in Patients with Cerebral Ischemia

Blood plasma proteome in patients with cerebral ischemia and healthy individuals was studied using comparative proteomic analysis based on tandem HPLC-MS/MS. Mass spectra were analysed in an automated mode using Progenesis LS-MS software and 256 proteins were identified. Significant quantitative dif...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2018-05, Vol.165 (1), p.22-26
Hauptverfasser:	Kisrieva, Yu. S., Petushkova, N. A., Samenkova, N. F., Kuznetsova, G. P., Larina, O. V., Teryaeva, N. B., Zgoda, V. G., Karuzina, I. I., Usachev, D. U., Belyaev, A. Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angiogenesis Apoptosis Biomedical and Life Sciences Biomedicine Blood Blood proteins Blood Proteins - analysis Brain damage Brain Ischemia - blood Care and treatment Cell Biology Cerebral Infarction - blood Cerebral ischemia Chaperones Chromatography, Liquid - methods Cytoskeleton Female Fibrinolysis High performance liquid chromatography Homeostasis Humans Immune system Internal Medicine Ischemia Laboratory Medicine Male Mass Spectrometry Middle Aged Pathology Plasma Protein composition Proteins Proteome - analysis Stroke
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Beschreibung
Zusammenfassung:	Blood plasma proteome in patients with cerebral ischemia and healthy individuals was studied using comparative proteomic analysis based on tandem HPLC-MS/MS. Mass spectra were analysed in an automated mode using Progenesis LS-MS software and 256 proteins were identified. Significant quantitative differences were revealed for 20 proteins. It was found that changes in the blood plasma proteome in subjects with cerebral ischemia involved a wide range of proteins: molecular chaperones, fibrinolysis, angiogenesis, and immune system proteins, proteins involved in homeostasis maintenance, cell differentiation and proliferation, regulators of apoptosis, and cytoskeleton proteins.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-018-4090-1