Predictors of mortality among hospitalized children with severe acute malnutrition: a prospective study from Uganda
Background We determined the predictors of mortality among children admitted with severe acute malnutrition (SAM). Methods This was a prospective study nested in a randomized trial among 6–59-month-old children admitted with SAM. Socio-demographic and medical history data were collected using questi...
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Veröffentlicht in: | Pediatric research 2018-07, Vol.84 (1), p.92-98 |
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Sprache: | eng |
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Zusammenfassung: | Background
We determined the predictors of mortality among children admitted with severe acute malnutrition (SAM).
Methods
This was a prospective study nested in a randomized trial among 6–59-month-old children admitted with SAM. Socio-demographic and medical history data were collected using questionnaires and clinical examination, anthropometry and laboratory tests were performed. They were monitored daily until discharge or death during hospitalization while receiving care according to national guidelines. Predictors of death were assessed using Cox regression.
Results
Of 400 children, 9.8% (
n
= 39) died during hospitalization. Predictors of mortality included diarrhoea at admission [hazard ratio [HR] 2.19, 95% confidence interval (CI): 1.06; 4.51], lack of appetite [HR 4.50, 95% CI: 1.76; 11.50], suspected sepsis [HR 2.23, 95% CI: 1.18; 4.24] and skin ulcers [HR 4.23, 95% CI: 1.26; 4.17]. Chest indrawing [HR 5.0, 95% CI: 1.53; 16.3], oxygen saturation below 94% [HR 3.92, 95% CI: 1.42; 10.83] and confirmed HIV infection [HR 3.62, 95% CI: 1.69; 7.77] also predicted higher mortality.
Conclusion
Infections were major contributors to mortality. This underscores the need for improved prevention and management of these infections among children with severe malnutrition. |
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ISSN: | 0031-3998 1530-0447 |
DOI: | 10.1038/s41390-018-0016-x |