Preparation of four 1,4‐dihydropyridine derivatives (DHPs) labeled with carbon‐14

Preparation of four 1,4‐dihydropyridine derivatives (DHPs) labeled with carbon‐14

The importance of DHPs compounds and the need for examining the mechanism of their effect, mandated us to synthesize a number of carbon‐14 labeled 1,4‐dihydropyridine derivatives for pharmacological studies. Simple preparation and suitable radiochemical yield were advantages of this preparation. In...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 2018-08, Vol.61 (10), p.796-798
Hauptverfasser: Faghih, Mohammad Amin Ahmadi, Moslemin, Mohammad Hossein, Shirvani, Gholamhossein, Javaheri, Mohsen
Format: Artikel
Sprache:eng
Schlagworte:
Antitubercular
Carbon
Carbon‐14
Derivatives
Dihydropyridine
Dihydropyridine (DHP)
labeling
Pharmacology
Radiochemistry
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Zusammenfassung:The importance of DHPs compounds and the need for examining the mechanism of their effect, mandated us to synthesize a number of carbon‐14 labeled 1,4‐dihydropyridine derivatives for pharmacological studies. Simple preparation and suitable radiochemical yield were advantages of this preparation. In this paper, 1,4‐dihydropyridine derivatives (DHPs) synthesis was developed, from 2 perspectives: the structural diversity of synthesis and the increasing number of labeled sites.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.3642