Shear stress sensitizes TRPV4 in endothelium-dependent vasodilatation

Shear stress sensitizes TRPV4 in endothelium-dependent vasodilatation

[Display omitted] The aim of this study was to better understand the role of TRPV4 in the regulation of blood vessel dilatation by blood flow and activation of GPCRs. Using pressure myography, the dilator responses to the TRPV4 agonist GSK1016790A and to acetylcholine, were examined in rat cremaster...

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Veröffentlicht in:Pharmacological research 2018-07, Vol.133, p.152-159
Hauptverfasser: Darby, William G., Potocnik, Simon, Ramachandran, Rithwik, Hollenberg, Morley D., Woodman, Owen L., McIntyre, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Blood flow
Cremaster arterioles
Endothelium-dependent vasodilatation
GPCR-dependent signalling
Muscarinic receptor
Pressure myography
Signalling TRPV4 ion channel
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Zusammenfassung:[Display omitted] The aim of this study was to better understand the role of TRPV4 in the regulation of blood vessel dilatation by blood flow and activation of GPCRs. Using pressure myography, the dilator responses to the TRPV4 agonist GSK1016790A and to acetylcholine, were examined in rat cremaster arterioles exposed to either no shear stress or to 200 μl/min flow for 6 min. In control vessels GSK1016709A caused vasodilatation (pEC50 7.73 ± 0.12 M, ΔDmax 97 ± 3%) which was significantly attenuated by the TRPV4 antagonists GSK2193874 (100 nM) (pEC50 6.19 ± 0.11 M, p 
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2018.05.009