Oral hydroxysafflor yellow A reduces obesity in mice by modulating the gut microbiota and serum metabolism

[Display omitted] Given the high and increasing prevalence of obesity, the safe and effective treatment of obesity would be beneficial. Here, we examined whether oral hydroxysafflor yellow A (HSYA), an active compound from the dried florets of Carthamus tinctorius L., can reduce high-fat (HF) diet-i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmacological research 2018-08, Vol.134, p.40-50
Hauptverfasser:	Liu, Juan, Yue, Shijun, Yang, Zhirui, Feng, Wuwen, Meng, Xintong, Wang, Aiting, Peng, Cheng, Wang, Changyun, Yan, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiposity - drug effects Administration, Oral Akkermansia Animals Anti-Obesity Agents - administration & dosage Bacteria - drug effects Bacteria - growth & development Bacteria - metabolism Biomarkers - blood Blood Glucose - metabolism Chalcone - administration & dosage Chalcone - analogs & derivatives Diet, High-Fat Disease Models, Animal Energy Metabolism - drug effects Fatty Acids, Volatile - blood Gastrointestinal Microbiome - drug effects Hydroxysafflor yellow A Insulin - blood Insulin Resistance Intestines - drug effects Intestines - microbiology Lysophosphatidylcholine Male Metabolomics - methods Mice, Inbred C57BL Obesity Obesity - blood Obesity - microbiology Obesity - physiopathology Obesity - prevention & control Quinones - administration & dosage Romboutsia Weight Loss - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	[Display omitted] Given the high and increasing prevalence of obesity, the safe and effective treatment of obesity would be beneficial. Here, we examined whether oral hydroxysafflor yellow A (HSYA), an active compound from the dried florets of Carthamus tinctorius L., can reduce high-fat (HF) diet-induced obesity in C57BL/6 J mice. Our results showed that the average body weight of HF group treated by HSYA was significantly lower than that of the HF group (P
ISSN:	1043-6618 1096-1186
DOI:	10.1016/j.phrs.2018.05.012