Liver injury induced by a Japanese herbal medicine, sairei‐to (TJ‐114, Bupleurum and Hoelen Combination, Chai‐Ling‐Tang) R1

The case is reported of a man who showed acute hepatitis with jaundice after he was given a Japanese herbal medicine, sairei‐to (TJ‐114, Bupleurum and Hoelen Combination, Chai‐Ling‐Tang). Unusually, the component thought to be responsible for the observed drug‐induced liver injury was able to be ide...

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Veröffentlicht in:	Journal of gastroenterology and hepatology 2007-05, Vol.22 (5), p.762-763
Hauptverfasser:	Aiba, Tsuneo, Takahashi, Toru, Suzuki, Kenji, Okoshi, Shogo, Nomoto, Minoru, Uno, Katsuji, Aoyagi, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Alanine Transaminase - blood Aspartate Aminotransferases - blood Bilirubin - blood Biological and medical sciences Bupleurum Cell Migration Inhibition Cell Movement - drug effects Chai‐Ling‐Tang Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - immunology Chemical and Drug Induced Liver Injury - metabolism Drugs, Chinese Herbal - adverse effects Drugs, Chinese Herbal - chemistry Fertility Agents, Male - adverse effects Fertility Agents, Male - chemistry Gastroenterology. Liver. Pancreas. Abdomen hepatitis herbal medicine Humans Jaundice - chemically induced Jaundice - enzymology Jaundice - immunology Jaundice - metabolism L-Lactate Dehydrogenase - blood liver Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymphocytes - drug effects Lymphocytes - immunology Male Medical sciences Other diseases. Semiology Pinellia Pinellia - adverse effects Plant Tubers - adverse effects sairei‐to (Bupleurum and Hoelen Combination Tuber
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Zusammenfassung:	The case is reported of a man who showed acute hepatitis with jaundice after he was given a Japanese herbal medicine, sairei‐to (TJ‐114, Bupleurum and Hoelen Combination, Chai‐Ling‐Tang). Unusually, the component thought to be responsible for the observed drug‐induced liver injury was able to be identified. Lymphocyte migration inhibition testing indicated that the tuber of the perennial herbage Pinellia ternate was the causative agent.
ISSN:	0815-9319 1440-1746
DOI:	10.1111/j.1440-1746.2006.03373.x