Clinical aspects of gastropathy development in patients with chronic obstructive pulmonary disease

Introduction: Chronic obstructive pulmonary disease (COPD) is a one of the main reasons of disability and mortality in the world. The essential attention is dedicated to the combination of COPD and erosive/ulcer defects with the haemorrhage risk factor. The aim was to compare gastric acidity and mucoid secretion in patients with chronic obstructive pulmonary disease of gastropathy development. Materials and methods: 94 patients with gastroduodenal erosive and ulcerous defects combined with COPD were examined. More than 50 % of patients (over 20 pack-years) had a long smoking history. Control group including 20 healthy voluntiers. Results: The mean age of patients was no difference in both groups. In regards to the severity of disease based on FEV1 30,9 % patients had mild obstruction and 69,1 % had moderate obstruction. Measurement of intragastric pH in patients with COPD and gastropathy showed the tendency of decreasing pH from 1,70±0,05 to 1,52±0,04 (р