Iron deficiency reduces systemic inflammation in obese women

Introduction: Iron plays an important role in the functioning of immunological monitoring due to its stimulating and differentiating effect on the immune system. Obesity is accompanied by chronic low grade inflammation and may be accompanied by a change in the concentration of iron in the blood serum. The aim of the study was to determine the level of systemic inflammation in iron deficiency anemia in patients with obesity. Materials and methods: 40 women with iron deficiency anemia (30 with obesity and 10 without obesity) and 10 with obesity of a similar age (control group) participated in the study. We evaluated hemogram parameters, indicators of iron exchange (serum iron, ferritin, hepcidin, total iron binding capacity, transferrin saturation) and inflammatory markers: C-reactive protein and interleukin-6 in the blood serum. Results: All patients were females with an average age of 40.3 ± 7.59 years. In the distribution of patients by the cause and the severity degree of iron deficiency anemia, there is no probable difference between the groups. C-reactive protein was significantly higher in women in the control group as compared with the groups of women with iron deficiency anemia (p 0.05). Interleukin-6 also had a higher level in the control group as compared with the groups of women who had iron deficiency anemia (p