A convergent strategy towards febrifugine and related compounds

A convergent strategy towards febrifugine and related compounds

We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate the application of a recent Rh-catalyzed quinazolinone synthesis for the faci...

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Veröffentlicht in:Organic & biomolecular chemistry 2018, Vol.16 (22), p.4159-4169
Hauptverfasser: Maiden, T M M, Mbelesi, N, Procopiou, P A, Swanson, S, Harrity, J P A
Format: Artikel
Sprache:eng
Schlagworte:
Chemical synthesis
Piperidine
Quinazolinone
Reagents
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Zusammenfassung:We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate the application of a recent Rh-catalyzed quinazolinone synthesis for the facile generation of febrifugine analogs.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob00935j