Incidence of major hemorrhage after aggressive image-guided liver mass biopsy in the era of individualized medicine
Purpose To analyze a large volume of image-guided liver mass biopsies to assess for an increased incidence of major hemorrhage after aggressive liver mass sampling, and to determine if coaxial technique reduces major hemorrhage rate. Methods Patients who underwent image-guided liver mass biopsy over...
Gespeichert in:
| Veröffentlicht in: | Abdominal imaging 2019-06, Vol.44 (6), p.2067-2073 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2073 |
|---|---|
| container_issue | 6 |
| container_start_page | 2067 |
| container_title | Abdominal imaging |
| container_volume | 44 |
| creator | Boyum, James H. Atwell, Thomas D. Wall, Darci J. Mansfield, Aaron S. Kerr, Sarah E. Gunderson, Tina M. Rumilla, Kandelaria M. Weisbrod, Adam J. Kurup, A. Nicholas |
| description | Purpose
To analyze a large volume of image-guided liver mass biopsies to assess for an increased incidence of major hemorrhage after aggressive liver mass sampling, and to determine if coaxial technique reduces major hemorrhage rate.
Methods
Patients who underwent image-guided liver mass biopsy over a 15-year period (December 7, 2001–September 22, 2016) were retrospectively identified. An aggressive biopsy was defined as a biopsy event in which ≥ 4 core needle passes were performed. Association of major hemorrhage after aggressive liver mass biopsy and other potential risk factors of interest were assessed using logistic regression analysis. For the subset of aggressive biopsies, Fisher’s exact test was used to compare the incidence of major hemorrhage using coaxial versus noncoaxial techniques.
Results
Aggressive biopsies constituted 11.6% of biopsy events (
N
=579/5011). The incidence of major hemorrhage with |
| doi_str_mv | 10.1007/s00261-018-1637-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2041630973</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2040395737</sourcerecordid><originalsourceid>FETCH-LOGICAL-p212t-8fa6bb7dcb78db4a602f4c684f6d2847d4018f2f9255e3218ddaa1a8bc1ae8483</originalsourceid><addsrcrecordid>eNpdkUtLAzEUhYMotmh_gBsJuHEzmtck6VKKj0LBjYK7kJncmabMoyadQv31prQquEq497uHe89B6IqSO0qIuo-EMEkzQnVGJVeZPEFjxqXMCMn16e9ffIzQJMYVIYTKnFKWn6MRmyoluKZjFOdd6R10JeC-wq1d9QEvoe1DWNoasK02ELCt6wAx-i1g36ZyVg9pxuEmVUIaihEXvl_HHfYd3iwBQ7B7Od85v_VusI3_SngLzpe-g0t0VtkmwuT4XqD3p8e32Uu2eH2ezx4W2ZpRtsl0ZWVRKFcWSrtCWElYJUqpRSUd00I5kW6vWDVleQ6cUe2ctdTqoqQWtND8At0edNeh_xwgbkzrYwlNYzvoh2gYEck5MlU8oTf_0FU_hC5tt6cIn-aKq0RdH6mhSMeYdUh2hJ35sTMB7ADE1OpqCH8ylJh9bOYQm0mrm31sRvJvtXKIvw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2040395737</pqid></control><display><type>article</type><title>Incidence of major hemorrhage after aggressive image-guided liver mass biopsy in the era of individualized medicine</title><source>SpringerLink Journals</source><creator>Boyum, James H. ; Atwell, Thomas D. ; Wall, Darci J. ; Mansfield, Aaron S. ; Kerr, Sarah E. ; Gunderson, Tina M. ; Rumilla, Kandelaria M. ; Weisbrod, Adam J. ; Kurup, A. Nicholas</creator><creatorcontrib>Boyum, James H. ; Atwell, Thomas D. ; Wall, Darci J. ; Mansfield, Aaron S. ; Kerr, Sarah E. ; Gunderson, Tina M. ; Rumilla, Kandelaria M. ; Weisbrod, Adam J. ; Kurup, A. Nicholas</creatorcontrib><description>Purpose
To analyze a large volume of image-guided liver mass biopsies to assess for an increased incidence of major hemorrhage after aggressive liver mass sampling, and to determine if coaxial technique reduces major hemorrhage rate.
Methods
Patients who underwent image-guided liver mass biopsy over a 15-year period (December 7, 2001–September 22, 2016) were retrospectively identified. An aggressive biopsy was defined as a biopsy event in which ≥ 4 core needle passes were performed. Association of major hemorrhage after aggressive liver mass biopsy and other potential risk factors of interest were assessed using logistic regression analysis. For the subset of aggressive biopsies, Fisher’s exact test was used to compare the incidence of major hemorrhage using coaxial versus noncoaxial techniques.
Results
Aggressive biopsies constituted 11.6% of biopsy events (
N
=579/5011). The incidence of major hemorrhage with <4 passes was 0.4% (
N
=18/4432) and with ≥4 passes 1.2% (
N
=6/579). In univariable models, aggressive biopsy was significantly associated with major hemorrhage (OR 3.0, 95% CI 1.16–6.92,
p
=0.025). After adjusting for gender and platelet count, the association was not significant at the
p
=0.05 level (OR 2.58, 95% CI 0.927–6.24,
p
=0.067). The rate of major hemorrhage in the coaxial biopsy technique group was 1.4% (
N
=3/209) compared to 1.1% (
N
=4/370) in the noncoaxial biopsy technique group, which was not a significant difference (
p
=0.707).
Conclusions
Although aggressive image-guided liver mass biopsies had an increased incidence of major hemorrhage, the overall risk of bleeding remained low. The benefit of such biopsies will almost certainly outweigh the risk in most patients.</description><identifier>ISSN: 2366-004X</identifier><identifier>EISSN: 2366-0058</identifier><identifier>DOI: 10.1007/s00261-018-1637-6</identifier><identifier>PMID: 29774381</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biopsy ; Bleeding ; Gastroenterology ; Hemorrhage ; Hepatology ; Imaging ; Incidence ; Liver ; Medicine ; Medicine & Public Health ; Radiology ; Regression analysis ; Risk analysis ; Risk factors</subject><ispartof>Abdominal imaging, 2019-06, Vol.44 (6), p.2067-2073</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Abdominal Radiology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p212t-8fa6bb7dcb78db4a602f4c684f6d2847d4018f2f9255e3218ddaa1a8bc1ae8483</cites><orcidid>0000-0002-7927-4834</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00261-018-1637-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00261-018-1637-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29774381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boyum, James H.</creatorcontrib><creatorcontrib>Atwell, Thomas D.</creatorcontrib><creatorcontrib>Wall, Darci J.</creatorcontrib><creatorcontrib>Mansfield, Aaron S.</creatorcontrib><creatorcontrib>Kerr, Sarah E.</creatorcontrib><creatorcontrib>Gunderson, Tina M.</creatorcontrib><creatorcontrib>Rumilla, Kandelaria M.</creatorcontrib><creatorcontrib>Weisbrod, Adam J.</creatorcontrib><creatorcontrib>Kurup, A. Nicholas</creatorcontrib><title>Incidence of major hemorrhage after aggressive image-guided liver mass biopsy in the era of individualized medicine</title><title>Abdominal imaging</title><addtitle>Abdom Radiol</addtitle><addtitle>Abdom Radiol (NY)</addtitle><description>Purpose
To analyze a large volume of image-guided liver mass biopsies to assess for an increased incidence of major hemorrhage after aggressive liver mass sampling, and to determine if coaxial technique reduces major hemorrhage rate.
Methods
Patients who underwent image-guided liver mass biopsy over a 15-year period (December 7, 2001–September 22, 2016) were retrospectively identified. An aggressive biopsy was defined as a biopsy event in which ≥ 4 core needle passes were performed. Association of major hemorrhage after aggressive liver mass biopsy and other potential risk factors of interest were assessed using logistic regression analysis. For the subset of aggressive biopsies, Fisher’s exact test was used to compare the incidence of major hemorrhage using coaxial versus noncoaxial techniques.
Results
Aggressive biopsies constituted 11.6% of biopsy events (
N
=579/5011). The incidence of major hemorrhage with <4 passes was 0.4% (
N
=18/4432) and with ≥4 passes 1.2% (
N
=6/579). In univariable models, aggressive biopsy was significantly associated with major hemorrhage (OR 3.0, 95% CI 1.16–6.92,
p
=0.025). After adjusting for gender and platelet count, the association was not significant at the
p
=0.05 level (OR 2.58, 95% CI 0.927–6.24,
p
=0.067). The rate of major hemorrhage in the coaxial biopsy technique group was 1.4% (
N
=3/209) compared to 1.1% (
N
=4/370) in the noncoaxial biopsy technique group, which was not a significant difference (
p
=0.707).
Conclusions
Although aggressive image-guided liver mass biopsies had an increased incidence of major hemorrhage, the overall risk of bleeding remained low. The benefit of such biopsies will almost certainly outweigh the risk in most patients.</description><subject>Biopsy</subject><subject>Bleeding</subject><subject>Gastroenterology</subject><subject>Hemorrhage</subject><subject>Hepatology</subject><subject>Imaging</subject><subject>Incidence</subject><subject>Liver</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Radiology</subject><subject>Regression analysis</subject><subject>Risk analysis</subject><subject>Risk factors</subject><issn>2366-004X</issn><issn>2366-0058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUtLAzEUhYMotmh_gBsJuHEzmtck6VKKj0LBjYK7kJncmabMoyadQv31prQquEq497uHe89B6IqSO0qIuo-EMEkzQnVGJVeZPEFjxqXMCMn16e9ffIzQJMYVIYTKnFKWn6MRmyoluKZjFOdd6R10JeC-wq1d9QEvoe1DWNoasK02ELCt6wAx-i1g36ZyVg9pxuEmVUIaihEXvl_HHfYd3iwBQ7B7Od85v_VusI3_SngLzpe-g0t0VtkmwuT4XqD3p8e32Uu2eH2ezx4W2ZpRtsl0ZWVRKFcWSrtCWElYJUqpRSUd00I5kW6vWDVleQ6cUe2ctdTqoqQWtND8At0edNeh_xwgbkzrYwlNYzvoh2gYEck5MlU8oTf_0FU_hC5tt6cIn-aKq0RdH6mhSMeYdUh2hJ35sTMB7ADE1OpqCH8ylJh9bOYQm0mrm31sRvJvtXKIvw</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Boyum, James H.</creator><creator>Atwell, Thomas D.</creator><creator>Wall, Darci J.</creator><creator>Mansfield, Aaron S.</creator><creator>Kerr, Sarah E.</creator><creator>Gunderson, Tina M.</creator><creator>Rumilla, Kandelaria M.</creator><creator>Weisbrod, Adam J.</creator><creator>Kurup, A. Nicholas</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7927-4834</orcidid></search><sort><creationdate>20190601</creationdate><title>Incidence of major hemorrhage after aggressive image-guided liver mass biopsy in the era of individualized medicine</title><author>Boyum, James H. ; Atwell, Thomas D. ; Wall, Darci J. ; Mansfield, Aaron S. ; Kerr, Sarah E. ; Gunderson, Tina M. ; Rumilla, Kandelaria M. ; Weisbrod, Adam J. ; Kurup, A. Nicholas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p212t-8fa6bb7dcb78db4a602f4c684f6d2847d4018f2f9255e3218ddaa1a8bc1ae8483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biopsy</topic><topic>Bleeding</topic><topic>Gastroenterology</topic><topic>Hemorrhage</topic><topic>Hepatology</topic><topic>Imaging</topic><topic>Incidence</topic><topic>Liver</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Radiology</topic><topic>Regression analysis</topic><topic>Risk analysis</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boyum, James H.</creatorcontrib><creatorcontrib>Atwell, Thomas D.</creatorcontrib><creatorcontrib>Wall, Darci J.</creatorcontrib><creatorcontrib>Mansfield, Aaron S.</creatorcontrib><creatorcontrib>Kerr, Sarah E.</creatorcontrib><creatorcontrib>Gunderson, Tina M.</creatorcontrib><creatorcontrib>Rumilla, Kandelaria M.</creatorcontrib><creatorcontrib>Weisbrod, Adam J.</creatorcontrib><creatorcontrib>Kurup, A. Nicholas</creatorcontrib><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Computer Science Collection</collection><collection>Computer Science Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Abdominal imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boyum, James H.</au><au>Atwell, Thomas D.</au><au>Wall, Darci J.</au><au>Mansfield, Aaron S.</au><au>Kerr, Sarah E.</au><au>Gunderson, Tina M.</au><au>Rumilla, Kandelaria M.</au><au>Weisbrod, Adam J.</au><au>Kurup, A. Nicholas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of major hemorrhage after aggressive image-guided liver mass biopsy in the era of individualized medicine</atitle><jtitle>Abdominal imaging</jtitle><stitle>Abdom Radiol</stitle><addtitle>Abdom Radiol (NY)</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>44</volume><issue>6</issue><spage>2067</spage><epage>2073</epage><pages>2067-2073</pages><issn>2366-004X</issn><eissn>2366-0058</eissn><abstract>Purpose
To analyze a large volume of image-guided liver mass biopsies to assess for an increased incidence of major hemorrhage after aggressive liver mass sampling, and to determine if coaxial technique reduces major hemorrhage rate.
Methods
Patients who underwent image-guided liver mass biopsy over a 15-year period (December 7, 2001–September 22, 2016) were retrospectively identified. An aggressive biopsy was defined as a biopsy event in which ≥ 4 core needle passes were performed. Association of major hemorrhage after aggressive liver mass biopsy and other potential risk factors of interest were assessed using logistic regression analysis. For the subset of aggressive biopsies, Fisher’s exact test was used to compare the incidence of major hemorrhage using coaxial versus noncoaxial techniques.
Results
Aggressive biopsies constituted 11.6% of biopsy events (
N
=579/5011). The incidence of major hemorrhage with <4 passes was 0.4% (
N
=18/4432) and with ≥4 passes 1.2% (
N
=6/579). In univariable models, aggressive biopsy was significantly associated with major hemorrhage (OR 3.0, 95% CI 1.16–6.92,
p
=0.025). After adjusting for gender and platelet count, the association was not significant at the
p
=0.05 level (OR 2.58, 95% CI 0.927–6.24,
p
=0.067). The rate of major hemorrhage in the coaxial biopsy technique group was 1.4% (
N
=3/209) compared to 1.1% (
N
=4/370) in the noncoaxial biopsy technique group, which was not a significant difference (
p
=0.707).
Conclusions
Although aggressive image-guided liver mass biopsies had an increased incidence of major hemorrhage, the overall risk of bleeding remained low. The benefit of such biopsies will almost certainly outweigh the risk in most patients.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29774381</pmid><doi>10.1007/s00261-018-1637-6</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7927-4834</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2366-004X |
| ispartof | Abdominal imaging, 2019-06, Vol.44 (6), p.2067-2073 |
| issn | 2366-004X 2366-0058 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2041630973 |
| source | SpringerLink Journals |
| subjects | Biopsy Bleeding Gastroenterology Hemorrhage Hepatology Imaging Incidence Liver Medicine Medicine & Public Health Radiology Regression analysis Risk analysis Risk factors |
| title | Incidence of major hemorrhage after aggressive image-guided liver mass biopsy in the era of individualized medicine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T11%3A42%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Incidence%20of%20major%20hemorrhage%20after%20aggressive%20image-guided%20liver%20mass%20biopsy%20in%20the%20era%20of%20individualized%20medicine&rft.jtitle=Abdominal%20imaging&rft.au=Boyum,%20James%20H.&rft.date=2019-06-01&rft.volume=44&rft.issue=6&rft.spage=2067&rft.epage=2073&rft.pages=2067-2073&rft.issn=2366-004X&rft.eissn=2366-0058&rft_id=info:doi/10.1007/s00261-018-1637-6&rft_dat=%3Cproquest_pubme%3E2040395737%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2040395737&rft_id=info:pmid/29774381&rfr_iscdi=true |