Neurocognitive dysfunction in subjects at clinical high risk for psychosis: A meta-analysis
Findings of neurocognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial. This meta-analysis systematically examined studies of neurocognitive functions using the MATRICS Consensus Cognitive Battery (MCCB) in CHR-P. An independent literature search of bo...
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Veröffentlicht in: | Journal of psychiatric research 2018-08, Vol.103, p.38-45 |
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creator | Zheng, Wei Zhang, Qing-E. Cai, Dong-Bin Ng, Chee H. Ungvari, Gabor S. Ning, Yu-Ping Xiang, Yu-Tao |
description | Findings of neurocognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial. This meta-analysis systematically examined studies of neurocognitive functions using the MATRICS Consensus Cognitive Battery (MCCB) in CHR-P. An independent literature search of both English and Chinese databases was conducted by two reviewers. Standardized mean difference (SMD) was calculated using a random effects model to evaluate the effect size of the meta-analytic results. Six case-control studies (n = 396) comparing neurocognitive functions between CHR-P subjects (n = 197) and healthy controls (n = 199) using the MCCB were identified; 4 (66.7%) studies were rated as “high quality”. Compared to healthy controls, CHR-P subjects showed impairment with large effect size in overall cognition (n = 128, SMD = −1.00, 95%CI: −1.38, −0.63, P |
doi_str_mv | 10.1016/j.jpsychires.2018.05.001 |
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•Findings of cognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial.•CHR-P subjects performed worse than healthy control in most cognitive domains.•A understanding of cognitive dysfunction in CHR-P is essential to develop interventions to improve cognitive impairment.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2018.05.001</identifier><identifier>PMID: 29772485</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Clinical high risk for psychosis ; MCCB ; Meta-analysis ; Neurocognitive function ; Psychosis ; Schizophrenia</subject><ispartof>Journal of psychiatric research, 2018-08, Vol.103, p.38-45</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-169641be444892c1a8236ea2fc2cdd03bdeeca079136aeb150f726b4473611f03</citedby><cites>FETCH-LOGICAL-c374t-169641be444892c1a8236ea2fc2cdd03bdeeca079136aeb150f726b4473611f03</cites><orcidid>0000-0002-3811-2732 ; 0000-0002-2906-0029</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpsychires.2018.05.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29772485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Wei</creatorcontrib><creatorcontrib>Zhang, Qing-E.</creatorcontrib><creatorcontrib>Cai, Dong-Bin</creatorcontrib><creatorcontrib>Ng, Chee H.</creatorcontrib><creatorcontrib>Ungvari, Gabor S.</creatorcontrib><creatorcontrib>Ning, Yu-Ping</creatorcontrib><creatorcontrib>Xiang, Yu-Tao</creatorcontrib><title>Neurocognitive dysfunction in subjects at clinical high risk for psychosis: A meta-analysis</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>Findings of neurocognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial. This meta-analysis systematically examined studies of neurocognitive functions using the MATRICS Consensus Cognitive Battery (MCCB) in CHR-P. An independent literature search of both English and Chinese databases was conducted by two reviewers. Standardized mean difference (SMD) was calculated using a random effects model to evaluate the effect size of the meta-analytic results. Six case-control studies (n = 396) comparing neurocognitive functions between CHR-P subjects (n = 197) and healthy controls (n = 199) using the MCCB were identified; 4 (66.7%) studies were rated as “high quality”. Compared to healthy controls, CHR-P subjects showed impairment with large effect size in overall cognition (n = 128, SMD = −1.00, 95%CI: −1.38, −0.63, P < 0.00001; I2 = 2%), processing speed (SMD = −1.21) and attention/vigilance (SMD = −0.83), and with medium effect size in working memory (SMD = −0.76), reasoning and problem solving (SMD = −0.71), visual (SMD = −0.68) and verbal learning (SMD = −0.67). No significant difference between CHR-P subjects and controls was found regarding social cognition (SMD = −0.33, 95%CI: −0.76, 0.10, P = 0.14; I2 = 70%) with small effect size. Apart from social cognition, CHR-P subjects performed worse than healthy control in all MCCB cognitive domains, particularly in processing speed, attention/vigilance and working memory.
•Findings of cognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial.•CHR-P subjects performed worse than healthy control in most cognitive domains.•A understanding of cognitive dysfunction in CHR-P is essential to develop interventions to improve cognitive impairment.</description><subject>Clinical high risk for psychosis</subject><subject>MCCB</subject><subject>Meta-analysis</subject><subject>Neurocognitive function</subject><subject>Psychosis</subject><subject>Schizophrenia</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v1DAQhi0EokvhLyAfuSTMOI6dcCsVX1IFFzhxsBxn0nXIxosnqbT_npQtcOQ00uj9mHmEkAglAprXYzke-RT2MROXCrApoS4B8JHYYWPbAivbPhY7AKWKqq3NhXjGPAKAVaifigvVWqt0U-_E98-05hTS7RyXeEeyP_GwzmGJaZZxlrx2I4WFpV9kmOIcg5_kPt7uZY78Qw4py9-HJI78Rl7JAy2-8LOfTtviuXgy-InpxcO8FN_ev_t6_bG4-fLh0_XVTREqq5cCTWs0dqS1bloV0DeqMuTVEFToe6i6nih4sC1WxlOHNQxWmU5rWxnEAapL8eqce8zp50q8uEPkQNPkZ0orOwUajaoB9CZtztKQE3OmwR1zPPh8cgjuHq0b3T-07h6tg9ptaDfry4eWtTtQ_9f4h-UmeHsW0PbrXaTsOESaA_VbVlhcn-L_W34BjFCQxA</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Zheng, Wei</creator><creator>Zhang, Qing-E.</creator><creator>Cai, Dong-Bin</creator><creator>Ng, Chee H.</creator><creator>Ungvari, Gabor S.</creator><creator>Ning, Yu-Ping</creator><creator>Xiang, Yu-Tao</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3811-2732</orcidid><orcidid>https://orcid.org/0000-0002-2906-0029</orcidid></search><sort><creationdate>201808</creationdate><title>Neurocognitive dysfunction in subjects at clinical high risk for psychosis: A meta-analysis</title><author>Zheng, Wei ; Zhang, Qing-E. ; Cai, Dong-Bin ; Ng, Chee H. ; Ungvari, Gabor S. ; Ning, Yu-Ping ; Xiang, Yu-Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-169641be444892c1a8236ea2fc2cdd03bdeeca079136aeb150f726b4473611f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Clinical high risk for psychosis</topic><topic>MCCB</topic><topic>Meta-analysis</topic><topic>Neurocognitive function</topic><topic>Psychosis</topic><topic>Schizophrenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Wei</creatorcontrib><creatorcontrib>Zhang, Qing-E.</creatorcontrib><creatorcontrib>Cai, Dong-Bin</creatorcontrib><creatorcontrib>Ng, Chee H.</creatorcontrib><creatorcontrib>Ungvari, Gabor S.</creatorcontrib><creatorcontrib>Ning, Yu-Ping</creatorcontrib><creatorcontrib>Xiang, Yu-Tao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Wei</au><au>Zhang, Qing-E.</au><au>Cai, Dong-Bin</au><au>Ng, Chee H.</au><au>Ungvari, Gabor S.</au><au>Ning, Yu-Ping</au><au>Xiang, Yu-Tao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurocognitive dysfunction in subjects at clinical high risk for psychosis: A meta-analysis</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2018-08</date><risdate>2018</risdate><volume>103</volume><spage>38</spage><epage>45</epage><pages>38-45</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><abstract>Findings of neurocognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial. This meta-analysis systematically examined studies of neurocognitive functions using the MATRICS Consensus Cognitive Battery (MCCB) in CHR-P. An independent literature search of both English and Chinese databases was conducted by two reviewers. Standardized mean difference (SMD) was calculated using a random effects model to evaluate the effect size of the meta-analytic results. Six case-control studies (n = 396) comparing neurocognitive functions between CHR-P subjects (n = 197) and healthy controls (n = 199) using the MCCB were identified; 4 (66.7%) studies were rated as “high quality”. Compared to healthy controls, CHR-P subjects showed impairment with large effect size in overall cognition (n = 128, SMD = −1.00, 95%CI: −1.38, −0.63, P < 0.00001; I2 = 2%), processing speed (SMD = −1.21) and attention/vigilance (SMD = −0.83), and with medium effect size in working memory (SMD = −0.76), reasoning and problem solving (SMD = −0.71), visual (SMD = −0.68) and verbal learning (SMD = −0.67). No significant difference between CHR-P subjects and controls was found regarding social cognition (SMD = −0.33, 95%CI: −0.76, 0.10, P = 0.14; I2 = 70%) with small effect size. Apart from social cognition, CHR-P subjects performed worse than healthy control in all MCCB cognitive domains, particularly in processing speed, attention/vigilance and working memory.
•Findings of cognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial.•CHR-P subjects performed worse than healthy control in most cognitive domains.•A understanding of cognitive dysfunction in CHR-P is essential to develop interventions to improve cognitive impairment.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29772485</pmid><doi>10.1016/j.jpsychires.2018.05.001</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3811-2732</orcidid><orcidid>https://orcid.org/0000-0002-2906-0029</orcidid></addata></record> |
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subjects | Clinical high risk for psychosis MCCB Meta-analysis Neurocognitive function Psychosis Schizophrenia |
title | Neurocognitive dysfunction in subjects at clinical high risk for psychosis: A meta-analysis |
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