Neurocognitive dysfunction in subjects at clinical high risk for psychosis: A meta-analysis

Findings of neurocognitive dysfunction in subjects at Clinical High Risk for Psychosis (CHR-P) have been controversial. This meta-analysis systematically examined studies of neurocognitive functions using the MATRICS Consensus Cognitive Battery (MCCB) in CHR-P. An independent literature search of both English and Chinese databases was conducted by two reviewers. Standardized mean difference (SMD) was calculated using a random effects model to evaluate the effect size of the meta-analytic results. Six case-control studies (n = 396) comparing neurocognitive functions between CHR-P subjects (n = 197) and healthy controls (n = 199) using the MCCB were identified; 4 (66.7%) studies were rated as “high quality”. Compared to healthy controls, CHR-P subjects showed impairment with large effect size in overall cognition (n = 128, SMD = −1.00, 95%CI: −1.38, −0.63, P