Decreased plasma levels of gasotransmitter hydrogen sulfide in patients with schizophrenia: correlation with psychopathology and cognition

Objective Aberrant N -methyl- d -aspartate receptor (NMDAR) function has been implicated in the pathophysiology of schizophrenia. Hydrogen sulfide (H 2 S) is an endogenous gasotransmitter that regulates NMDAR function. The current study investigated the relationship between plasma H 2 S levels and both psychopathological and cognitive symptoms in schizophrenia. Materials and methods Forty-one patients with schizophrenia and 40 healthy control subjects were recruited in present study. Schizophrenic symptomatology was assessed using the Positive and Negative Syndrome Scale (PANSS). Cognitive function was evaluated with a neuropsychological battery including seven neurocognitive tests. Plasma H 2 S levels were measured by reversed-phase high-performance liquid chromatography (RP-HPLC). Results Patients with schizophrenia performed worse in all of the cognitive tests than the healthy controls except for the visual memory. Plasma H 2 S levels were significantly lower in patients with schizophrenia relative to healthy control subjects ( F = 3.821, p = 0.007). Correlation analysis revealed a significant negative correlation between the H 2 S levels and the PANSS general scores ( r = − 0.413, p = 0.007). Additionally, a positive association was observed between plasma H 2 S levels and working memory ( r = 0.416, p = 0.007), visual memory ( r = 0.363, p = 0.020), or executive function ( r = 0.344, p = 0.028) in patients. Partial correlation analysis showed that the correlations between the H 2 S levels and the PANSS general scores, working memory, visual memory, or executive function were still significant when controlling for age, gender, years of education, BMI, duration of illness, and age of onset. Conclusion The significant relations observed in the current study between H 2 S and the general psychopathological as well as cognitive symptoms suggest that decreased H 2 S is involved in the psychopathology and cognitive deficits of schizophrenia, and it might be a promising peripheral biomarker of schizophrenia.