Activation of map kinase signalling via ERK5 but not ERK1 expression is associated with lymph node metastases in oral squamous cell carcinoma (OSCC)

Activation of map kinase signalling via ERK5 but not ERK1 expression is associated with lymph node metastases in oral squamous cell carcinoma (OSCC)

In an attempt to further elucidate the pathomechanisms in oral squamous cell carcinoma (OSCC), gene expression profiling using a whole-transcriptome chip that contains 35,035 gene-specific 70mere oligonucleotides (Human Oligoset 4.0; Operon) to a set of 35 primary OSCCs. Altogether, 7390 genes were...

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Veröffentlicht in:Neoplasia (New York, N.Y.) N.Y.), 2008-05, Vol.10 (5)
Hauptverfasser: Sticht, C, Freier, K, Knoepfle, K, Flechtenmacher, C, Pungs, S, Christof, H M, Hahn, M, Joos, S, Lichter, P
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Sprache:eng
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Zusammenfassung:In an attempt to further elucidate the pathomechanisms in oral squamous cell carcinoma (OSCC), gene expression profiling using a whole-transcriptome chip that contains 35,035 gene-specific 70mere oligonucleotides (Human Oligoset 4.0; Operon) to a set of 35 primary OSCCs. Altogether, 7390 genes were found differentially expressed between OSCC tumor samples and oral mucosa. To characterize the major biological processes in this tumor collection, MAPPFinder, a component of GenMAPP version 2.1, was applied to this data set to generate a statistically ranked list of molecular signalling pathways. Among others, cancer-related pathways like MAP kinase signalling (z-score=4.6, p
ISSN:1522-8002