Rapid Progression of Adult T-Cell Leukemia–Lymphoma after PD-1 Inhibitor Therapy

Three patients with chronic, smoldering, and acute subtypes of adult T-cell leukemia–lymphoma had rapid disease progression and increased viral replication after treatment with the anti–programmed death 1 antibody nivolumab.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-05, Vol.378 (20), p.1947-1948
Hauptverfasser:	Ratner, Lee, Waldmann, Thomas A, Janakiram, Murali, Brammer, Jonathan E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Disease Progression Humans Leukemia-Lymphoma, Adult T-Cell - drug therapy Programmed Cell Death 1 Receptor - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	Three patients with chronic, smoldering, and acute subtypes of adult T-cell leukemia–lymphoma had rapid disease progression and increased viral replication after treatment with the anti–programmed death 1 antibody nivolumab.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMc1803181