Interleukin-4 as a Neuromodulatory Cytokine

Interleukin-4 as a Neuromodulatory Cytokine

Although interleukin (IL)‐4 is described as a prototypical anti‐inflammatory cytokine, in recent years its role as a neuromodulatory cytokine has been extensively discussed. This review highlights the pivotal contributions of IL‐4 during the development and normal physiology of neural cells as well...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2009-02, Vol.1153 (1), p.65-75
Hauptverfasser: Sholl-Franco, Alfred, Da Silva, Ana Gabriela Ledo Santos, Adão-Novaes, Juliana
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Sprache:eng
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cell signaling
development
interleukin-4
nervous system
neuroimmunomodulation
neuroinflammation
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container_title Annals of the New York Academy of Sciences
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creator Sholl-Franco, Alfred
Da Silva, Ana Gabriela Ledo Santos
Adão-Novaes, Juliana
description Although interleukin (IL)‐4 is described as a prototypical anti‐inflammatory cytokine, in recent years its role as a neuromodulatory cytokine has been extensively discussed. This review highlights the pivotal contributions of IL‐4 during the development and normal physiology of neural cells as well as IL‐4 connections with the pathophysiology of degenerative or inflammatory processes observed in the central and peripheral nervous system.
doi_str_mv 10.1111/j.1749-6632.2008.03962.x
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1749-6632
1930-6547
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source Wiley Online Library Journals Frontfile Complete
subjects cell signaling
development
interleukin-4
nervous system
neuroimmunomodulation
neuroinflammation
title Interleukin-4 as a Neuromodulatory Cytokine
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