Interleukin-4 as a Neuromodulatory Cytokine

Interleukin-4 as a Neuromodulatory Cytokine

Although interleukin (IL)‐4 is described as a prototypical anti‐inflammatory cytokine, in recent years its role as a neuromodulatory cytokine has been extensively discussed. This review highlights the pivotal contributions of IL‐4 during the development and normal physiology of neural cells as well...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2009-02, Vol.1153 (1), p.65-75
Hauptverfasser: Sholl-Franco, Alfred, Da Silva, Ana Gabriela Ledo Santos, Adão-Novaes, Juliana
Format: Artikel
Sprache:eng
Schlagworte:
cell signaling
development
interleukin-4
nervous system
neuroimmunomodulation
neuroinflammation
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Zusammenfassung:Although interleukin (IL)‐4 is described as a prototypical anti‐inflammatory cytokine, in recent years its role as a neuromodulatory cytokine has been extensively discussed. This review highlights the pivotal contributions of IL‐4 during the development and normal physiology of neural cells as well as IL‐4 connections with the pathophysiology of degenerative or inflammatory processes observed in the central and peripheral nervous system.
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1111/j.1749-6632.2008.03962.x