Discontinued drugs in 2007: anti-infectives

Twelve drugs related to therapy and/or prevention of infectious diseases were discontinued from development during 2007. All of these agents were aimed at viral infections, primarily hepatitis C virus (six agents) and HIV (five agents). Nearly half were vaccines, including three against HIV, a thera...

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Veröffentlicht in:	Expert opinion on investigational drugs 2009-01, Vol.18 (1), p.1-11
1. Verfasser:	Ryder, Neil S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - adverse effects Anti-Infective Agents - supply & distribution anti-infectives discontinued drugs HCV Hepatitis C virus herpes virus HIV Human immunodeficiency virus Humans Time Factors Treatment Failure vaccine Viral Vaccines - supply & distribution
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Zusammenfassung:	Twelve drugs related to therapy and/or prevention of infectious diseases were discontinued from development during 2007. All of these agents were aimed at viral infections, primarily hepatitis C virus (six agents) and HIV (five agents). Nearly half were vaccines, including three against HIV, a therapeutic vaccine for hepatitis C, and a vaccine for prevention and treatment of herpes simplex virus type 2. Each of these agents is briefly reviewed and the reasons for failure are discussed.
ISSN:	1354-3784 1744-7658
DOI:	10.1517/13543780802614920