Broad collateral damage of drugs against the gut microbiome

Broad collateral damage of drugs against the gut microbiome

In a new study, Maier et al. reveal that non-antibiotic drugs intended to target human cells have off-target effects on the growth of human gut bacteria at clinically relevant concentrations. These results emphasize the need for a new field of metagenomic toxicology aimed at a more comprehensive und...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature reviews. Gastroenterology & hepatology 2018-08, Vol.15 (8), p.457-458
Hauptverfasser: Spanogiannopoulos, Peter, Turnbaugh, Peter J.
Format: Artikel
Sprache:eng
Schlagworte:
631/326/2565/2134
631/326/41/1969/2038
692/4020/2741/2135
Bacteria
Biomedicine
Digestive system
Gastroenterology
Gastrointestinal Microbiome
Hepatology
Humans
Intestinal microflora
Medicine
Medicine & Public Health
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
News & Views
news-and-views
Toxicity
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In a new study, Maier et al. reveal that non-antibiotic drugs intended to target human cells have off-target effects on the growth of human gut bacteria at clinically relevant concentrations. These results emphasize the need for a new field of metagenomic toxicology aimed at a more comprehensive understanding of the toxicity of compounds for humans and their associated microbial communities.
ISSN:1759-5045
1759-5053
DOI:10.1038/s41575-018-0028-3