Placental DNA Methylation Adaptation to Maternal Glycemic Response in Pregnancy

Maternal hyperglycemia during pregnancy is associated with excess fetal growth and adverse perinatal and developmental outcomes. Placental epigenetic maladaptation may underlie these associations. We performed an epigenome-wide association study (>850,000 CpG sites) of term placentas and prenatal...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2018-08, Vol.67 (8), p.1673-1683
Hauptverfasser:	Cardenas, Andres, Gagné-Ouellet, Valerie, Allard, Catherine, Brisson, Diane, Perron, Patrice, Bouchard, Luigi, Hivert, Marie-France
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers - blood Biomarkers - metabolism Birth Weight Blood glucose Cohort Studies CpG Islands Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism DNA Methylation Epigenesis, Genetic Epigenetics Female Fetuses Gene Expression Regulation, Developmental Gestation Glucose Glucose Tolerance Test Glycated Hemoglobin A - analysis Humans Hyperglycemia Infant, Newborn Inflammation Inflammatory diseases Insulin Resistance Phosphodiesterase Placenta Placenta - enzymology Placenta - metabolism Placentation Pregnancy Prospective Studies Receptors, LDL - genetics Receptors, LDL - metabolism Receptors, Tumor Necrosis Factor, Type II - genetics Receptors, Tumor Necrosis Factor, Type II - metabolism RecQ Helicases - genetics RecQ Helicases - metabolism Term Birth Young Adult
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Zusammenfassung:	Maternal hyperglycemia during pregnancy is associated with excess fetal growth and adverse perinatal and developmental outcomes. Placental epigenetic maladaptation may underlie these associations. We performed an epigenome-wide association study (>850,000 CpG sites) of term placentas and prenatal maternal glycemic response 2-h post oral glucose challenge at 24-30 weeks of gestation among 448 mother-infant pairs. Maternal 2-h glycemia postload was strongly associated with lower DNA methylation of four CpG sites (false discovery rate [FDR]
ISSN:	0012-1797 1939-327X
DOI:	10.2337/db18-0123