Local Low Shear Stress and Endothelial Dysfunction in Patients With Nonobstructive Coronary Atherosclerosis

Local hemodynamic factors are important determinants of atherosclerotic plaque development and progression. The goal of this study was to determine the association between low endothelial shear stress (ESS) and microvascular and epicardial endothelial dysfunction in patients with early atheroscleros...

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Veröffentlicht in:	Journal of the American College of Cardiology 2018-05, Vol.71 (19), p.2092-2102
Hauptverfasser:	Siasos, Gerasimos, Sara, Jaskanwal D., Zaromytidou, Marina, Park, Kyoung H., Coskun, Ahmet Umit, Lerman, Lilach O., Oikonomou, Evangelos, Maynard, Charles C., Fotiadis, Dimitris, Stefanou, Kostas, Papafaklis, Michail, Michalis, Lampros, Feldman, Charles, Lerman, Amir, Stone, Peter H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Adult Angiography Arteries Arteriosclerosis Atherosclerosis Blood pressure Cardiology Cardiovascular disease Computational fluid dynamics coronary artery disease Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - physiopathology Coronary vessels endothelial function endothelial shear stress Endothelium Endothelium, Vascular - diagnostic imaging Endothelium, Vascular - physiopathology Female Fluid dynamics Health risk assessment Humans Hydrodynamics Hypertension Male Medical imaging microvascular disease Microvasculature Middle Aged Patients Prospective Studies Random Allocation Regression analysis Retrospective Studies Segments Shear Strength - physiology Shear stress Stenosis Stress, Mechanical Ultrasound
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Zusammenfassung:	Local hemodynamic factors are important determinants of atherosclerotic plaque development and progression. The goal of this study was to determine the association between low endothelial shear stress (ESS) and microvascular and epicardial endothelial dysfunction in patients with early atherosclerosis. Sixty-five patients (mean age 52 ± 11 years) with nonobstructive coronary atherosclerosis (luminal diameter stenosis
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2018.02.073