Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery
Patients undergoing major abdominal surgery received restrictive or liberal intravenous fluids during surgery and up to 24 hours thereafter. The restrictive regimen did not improve disability-free survival and resulted in increased acute kidney injury.
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| Veröffentlicht in: | The New England journal of medicine 2018-06, Vol.378 (24), p.2263-2274 |
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| container_title | The New England journal of medicine |
| container_volume | 378 |
| creator | Myles, Paul S Bellomo, Rinaldo Corcoran, Tomas Forbes, Andrew Peyton, Philip Story, David Christophi, Chris Leslie, Kate McGuinness, Shay Parke, Rachael Serpell, Jonathan Chan, Matthew T.V Painter, Thomas McCluskey, Stuart Minto, Gary Wallace, Sophie |
| description | Patients undergoing major abdominal surgery received restrictive or liberal intravenous fluids during surgery and up to 24 hours thereafter. The restrictive regimen did not improve disability-free survival and resulted in increased acute kidney injury. |
| doi_str_mv | 10.1056/NEJMoa1801601 |
| format | Article |
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The restrictive regimen did not improve disability-free survival and resulted in increased acute kidney injury.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1801601</identifier><identifier>PMID: 29742967</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Abdomen ; Abdomen - surgery ; Abdominal surgery ; Acute Kidney Injury - etiology ; Aged ; Anesthesia ; Blood Loss, Surgical ; Death ; Design ; Digestive System Surgical Procedures - adverse effects ; Digestive System Surgical Procedures - mortality ; Drug dosages ; Female ; Fluid intake ; Fluid Therapy - adverse effects ; Fluid Therapy - methods ; Fluids ; Follow-Up Studies ; Hospitals ; Humans ; Hypotonic Solutions - administration & dosage ; Hypotonic Solutions - adverse effects ; Intravenous administration ; Kidneys ; Laparoscopy ; Male ; Medical research ; Middle Aged ; Perfusion ; Postoperative Complications - epidemiology ; Postoperative Complications - prevention & control ; Rehydration Solutions - administration & dosage ; Rehydration Solutions - adverse effects ; Rehydration Solutions - chemistry ; Risk Factors ; Surgery ; Surgical site infections ; Survival ; Systemic diseases</subject><ispartof>The New England journal of medicine, 2018-06, Vol.378 (24), p.2263-2274</ispartof><rights>Copyright © 2018 Massachusetts Medical Society. 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The restrictive regimen did not improve disability-free survival and resulted in increased acute kidney injury.</description><subject>Abdomen</subject><subject>Abdomen - surgery</subject><subject>Abdominal surgery</subject><subject>Acute Kidney Injury - etiology</subject><subject>Aged</subject><subject>Anesthesia</subject><subject>Blood Loss, Surgical</subject><subject>Death</subject><subject>Design</subject><subject>Digestive System Surgical Procedures - adverse effects</subject><subject>Digestive System Surgical Procedures - mortality</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Fluid intake</subject><subject>Fluid Therapy - adverse effects</subject><subject>Fluid Therapy - methods</subject><subject>Fluids</subject><subject>Follow-Up Studies</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypotonic Solutions - administration & dosage</subject><subject>Hypotonic Solutions - adverse effects</subject><subject>Intravenous administration</subject><subject>Kidneys</subject><subject>Laparoscopy</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Perfusion</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - prevention & control</subject><subject>Rehydration Solutions - administration & dosage</subject><subject>Rehydration Solutions - adverse effects</subject><subject>Rehydration Solutions - chemistry</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Surgical site infections</subject><subject>Survival</subject><subject>Systemic diseases</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10NtLwzAYBfAgipvTR1-lIIIv1dwvjzI3L2wKOp9L2n7VlnadyTrYf2_GpqBgHhICPw6Hg9ApwVcEC3n9NHqctpZoTCQme6hPBGMx51juoz7GVMdcGdZDR95XOBzCzSHqUaM4NVL10e0L-KUrs2W5gmgFznc-mpQpOFtH47or82j2ET6LdVS0LpraKtw3ad425TyI1869g1sfo4PC1h5Odu8AvY1Hs-F9PHm-exjeTOKMC7mMCUijc6GpLEBjURjBM7CYEc14VkgBoV1uSC4tZZSSnJM01aA5tlplCgQboMtt7sK1n10onjSlz6Cu7RzazicUM4WFVkwFev6HVm3nQueNUphpZRQLKt6qzLXeOyiShSsb69YJwclm3uTXvMGf7VK7tIH8R3_vGcDFFjSNT-ZQNf8EfQFXp37U</recordid><startdate>20180614</startdate><enddate>20180614</enddate><creator>Myles, Paul S</creator><creator>Bellomo, Rinaldo</creator><creator>Corcoran, Tomas</creator><creator>Forbes, Andrew</creator><creator>Peyton, Philip</creator><creator>Story, David</creator><creator>Christophi, Chris</creator><creator>Leslie, Kate</creator><creator>McGuinness, Shay</creator><creator>Parke, Rachael</creator><creator>Serpell, Jonathan</creator><creator>Chan, Matthew T.V</creator><creator>Painter, Thomas</creator><creator>McCluskey, Stuart</creator><creator>Minto, Gary</creator><creator>Wallace, Sophie</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180614</creationdate><title>Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery</title><author>Myles, Paul S ; Bellomo, Rinaldo ; Corcoran, Tomas ; Forbes, Andrew ; Peyton, Philip ; Story, David ; Christophi, Chris ; Leslie, Kate ; McGuinness, Shay ; Parke, Rachael ; Serpell, Jonathan ; Chan, Matthew T.V ; Painter, Thomas ; McCluskey, Stuart ; Minto, Gary ; Wallace, Sophie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-1e698d5826fe805f954cea031834cf65e014d91d6a23221d41bb8e840a87c7e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abdomen</topic><topic>Abdomen - 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| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2018-06, Vol.378 (24), p.2263-2274 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Abdomen Abdomen - surgery Abdominal surgery Acute Kidney Injury - etiology Aged Anesthesia Blood Loss, Surgical Death Design Digestive System Surgical Procedures - adverse effects Digestive System Surgical Procedures - mortality Drug dosages Female Fluid intake Fluid Therapy - adverse effects Fluid Therapy - methods Fluids Follow-Up Studies Hospitals Humans Hypotonic Solutions - administration & dosage Hypotonic Solutions - adverse effects Intravenous administration Kidneys Laparoscopy Male Medical research Middle Aged Perfusion Postoperative Complications - epidemiology Postoperative Complications - prevention & control Rehydration Solutions - administration & dosage Rehydration Solutions - adverse effects Rehydration Solutions - chemistry Risk Factors Surgery Surgical site infections Survival Systemic diseases |
| title | Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery |
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