The best of two worlds? Pulmonary vein isolation using a novel radiofrequency ablation catheter incorporating contact force sensing technology and 56-hole porous tip irrigation

Aims This study aimed to evaluate feasibility and safety as well as 1-year clinical outcome of pulmonary vein isolation (PVI) using a unique radiofrequency ablation catheter (“Thermocool SmartTouch SurroundFlow”; STSF) incorporating both, contact force (CF) sensing technology and enhanced tip irriga...

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Veröffentlicht in:Clinical research in cardiology 2018-11, Vol.107 (11), p.1003-1012
Hauptverfasser: Maurer, Tilman, Rottner, Laura, Makimoto, Hisaki, Reissmann, Bruno, Heeger, Christian-H., Lemes, Christine, Fink, Thomas, Riedl, Johannes, Santoro, Francesco, Wohlmuth, Peter, Volkmer, Marius, Mathew, Shibu, Metzner, Andreas, Ouyang, Feifan, Kuck, Karl-Heinz, Sohns, Christian
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container_end_page 1012
container_issue 11
container_start_page 1003
container_title Clinical research in cardiology
container_volume 107
creator Maurer, Tilman
Rottner, Laura
Makimoto, Hisaki
Reissmann, Bruno
Heeger, Christian-H.
Lemes, Christine
Fink, Thomas
Riedl, Johannes
Santoro, Francesco
Wohlmuth, Peter
Volkmer, Marius
Mathew, Shibu
Metzner, Andreas
Ouyang, Feifan
Kuck, Karl-Heinz
Sohns, Christian
description Aims This study aimed to evaluate feasibility and safety as well as 1-year clinical outcome of pulmonary vein isolation (PVI) using a unique radiofrequency ablation catheter (“Thermocool SmartTouch SurroundFlow”; STSF) incorporating both, contact force (CF) sensing technology and enhanced tip irrigation with 56 holes, in one device. Methods A total of 110 patients suffering from drug-refractory atrial fibrillation underwent wide area circumferential PVI using either the STSF ablation catheter (75 consecutive patients, study group) or a CF catheter with conventional tip irrigation (“Thermocool SmartTouch”, 35 consecutive patients, control group). For each ablation lesion, a target CF of ≥ 10–39 g and a force time integral (FTI) of > 400 g s was targeted. Results Acute PVI was achieved in all patients with target CF obtained in > 85% of ablation points when using either device. Mean procedure time (131.3 ± 33.7 min in the study group vs. 133.0 ± 42.0 min in the control group; p  = 0.99), mean fluoroscopy time (14.0 ± 6 vs. 13.5 ± 6.6 min; p  = 0.56) and total ablation time were not significantly different (1751.0 ± 394.0 vs. 1604.6 ± 287.8 s; p  = 0.2). However, there was a marked reduction in total irrigation fluid delivery by 51.7% (265.52 ± 64.4 vs. 539.6 ± 118.2 ml; p  
doi_str_mv 10.1007/s00392-018-1270-y
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Pulmonary vein isolation using a novel radiofrequency ablation catheter incorporating contact force sensing technology and 56-hole porous tip irrigation</title><source>SpringerLink Journals - AutoHoldings</source><creator>Maurer, Tilman ; Rottner, Laura ; Makimoto, Hisaki ; Reissmann, Bruno ; Heeger, Christian-H. ; Lemes, Christine ; Fink, Thomas ; Riedl, Johannes ; Santoro, Francesco ; Wohlmuth, Peter ; Volkmer, Marius ; Mathew, Shibu ; Metzner, Andreas ; Ouyang, Feifan ; Kuck, Karl-Heinz ; Sohns, Christian</creator><creatorcontrib>Maurer, Tilman ; Rottner, Laura ; Makimoto, Hisaki ; Reissmann, Bruno ; Heeger, Christian-H. ; Lemes, Christine ; Fink, Thomas ; Riedl, Johannes ; Santoro, Francesco ; Wohlmuth, Peter ; Volkmer, Marius ; Mathew, Shibu ; Metzner, Andreas ; Ouyang, Feifan ; Kuck, Karl-Heinz ; Sohns, Christian</creatorcontrib><description>Aims This study aimed to evaluate feasibility and safety as well as 1-year clinical outcome of pulmonary vein isolation (PVI) using a unique radiofrequency ablation catheter (“Thermocool SmartTouch SurroundFlow”; STSF) incorporating both, contact force (CF) sensing technology and enhanced tip irrigation with 56 holes, in one device. Methods A total of 110 patients suffering from drug-refractory atrial fibrillation underwent wide area circumferential PVI using either the STSF ablation catheter (75 consecutive patients, study group) or a CF catheter with conventional tip irrigation (“Thermocool SmartTouch”, 35 consecutive patients, control group). For each ablation lesion, a target CF of ≥ 10–39 g and a force time integral (FTI) of &gt; 400 g s was targeted. Results Acute PVI was achieved in all patients with target CF obtained in &gt; 85% of ablation points when using either device. Mean procedure time (131.3 ± 33.7 min in the study group vs. 133.0 ± 42.0 min in the control group; p  = 0.99), mean fluoroscopy time (14.0 ± 6 vs. 13.5 ± 6.6 min; p  = 0.56) and total ablation time were not significantly different (1751.0 ± 394.0 vs. 1604.6 ± 287.8 s; p  = 0.2). However, there was a marked reduction in total irrigation fluid delivery by 51.7% (265.52 ± 64.4 vs. 539.6 ± 118.2 ml; p  &lt; 0.01). The Kaplan–Meier estimate 12-month arrhythmia–free survival after the index procedure following a 3-month blanking period was 79.9% (95% CI 70.4%, 90.4%) for the study group and 66.7% for the control group (95% CI 50.2%, 88.5%). This finding did not reach statistical significance ( p  = 0.18). Major complications occurred in 2/75 patients (2.7%; one pericardial tamponade and one transient ischemic attack) in the study group and no patient in the control group ( p  = 18). Conclusion PVI using the STSF catheter is safe and effective and results in beneficial 1-year clinical outcome. The improved tip irrigation leads to a significant reduction in procedural fluid burden.</description><identifier>ISSN: 1861-0684</identifier><identifier>EISSN: 1861-0692</identifier><identifier>DOI: 10.1007/s00392-018-1270-y</identifier><identifier>PMID: 29740700</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Ablation ; Arrhythmia ; Blanking ; Cardiology ; Complications ; Contact force ; Feasibility studies ; Fibrillation ; Fluoroscopy ; Intubation ; Ischemia ; Lavage ; Medical instruments ; Medical technology ; Medicine ; Medicine &amp; Public Health ; Original Paper ; Patients ; Pulmonary arteries ; Radio frequency ; Radiofrequency ablation ; Reduction ; Sensors ; Tamponade ; Technology ; Transient ischemic attack</subject><ispartof>Clinical research in cardiology, 2018-11, Vol.107 (11), p.1003-1012</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Clinical Research in Cardiology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-7e2ccbf15d0e01bd3ad6f69e93d57b18f99d3aa44ac023e9694f50f1551555e83</citedby><cites>FETCH-LOGICAL-c438t-7e2ccbf15d0e01bd3ad6f69e93d57b18f99d3aa44ac023e9694f50f1551555e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00392-018-1270-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00392-018-1270-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29740700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maurer, Tilman</creatorcontrib><creatorcontrib>Rottner, Laura</creatorcontrib><creatorcontrib>Makimoto, Hisaki</creatorcontrib><creatorcontrib>Reissmann, Bruno</creatorcontrib><creatorcontrib>Heeger, Christian-H.</creatorcontrib><creatorcontrib>Lemes, Christine</creatorcontrib><creatorcontrib>Fink, Thomas</creatorcontrib><creatorcontrib>Riedl, Johannes</creatorcontrib><creatorcontrib>Santoro, Francesco</creatorcontrib><creatorcontrib>Wohlmuth, Peter</creatorcontrib><creatorcontrib>Volkmer, Marius</creatorcontrib><creatorcontrib>Mathew, Shibu</creatorcontrib><creatorcontrib>Metzner, Andreas</creatorcontrib><creatorcontrib>Ouyang, Feifan</creatorcontrib><creatorcontrib>Kuck, Karl-Heinz</creatorcontrib><creatorcontrib>Sohns, Christian</creatorcontrib><title>The best of two worlds? Pulmonary vein isolation using a novel radiofrequency ablation catheter incorporating contact force sensing technology and 56-hole porous tip irrigation</title><title>Clinical research in cardiology</title><addtitle>Clin Res Cardiol</addtitle><addtitle>Clin Res Cardiol</addtitle><description>Aims This study aimed to evaluate feasibility and safety as well as 1-year clinical outcome of pulmonary vein isolation (PVI) using a unique radiofrequency ablation catheter (“Thermocool SmartTouch SurroundFlow”; STSF) incorporating both, contact force (CF) sensing technology and enhanced tip irrigation with 56 holes, in one device. Methods A total of 110 patients suffering from drug-refractory atrial fibrillation underwent wide area circumferential PVI using either the STSF ablation catheter (75 consecutive patients, study group) or a CF catheter with conventional tip irrigation (“Thermocool SmartTouch”, 35 consecutive patients, control group). For each ablation lesion, a target CF of ≥ 10–39 g and a force time integral (FTI) of &gt; 400 g s was targeted. Results Acute PVI was achieved in all patients with target CF obtained in &gt; 85% of ablation points when using either device. Mean procedure time (131.3 ± 33.7 min in the study group vs. 133.0 ± 42.0 min in the control group; p  = 0.99), mean fluoroscopy time (14.0 ± 6 vs. 13.5 ± 6.6 min; p  = 0.56) and total ablation time were not significantly different (1751.0 ± 394.0 vs. 1604.6 ± 287.8 s; p  = 0.2). However, there was a marked reduction in total irrigation fluid delivery by 51.7% (265.52 ± 64.4 vs. 539.6 ± 118.2 ml; p  &lt; 0.01). The Kaplan–Meier estimate 12-month arrhythmia–free survival after the index procedure following a 3-month blanking period was 79.9% (95% CI 70.4%, 90.4%) for the study group and 66.7% for the control group (95% CI 50.2%, 88.5%). This finding did not reach statistical significance ( p  = 0.18). Major complications occurred in 2/75 patients (2.7%; one pericardial tamponade and one transient ischemic attack) in the study group and no patient in the control group ( p  = 18). Conclusion PVI using the STSF catheter is safe and effective and results in beneficial 1-year clinical outcome. The improved tip irrigation leads to a significant reduction in procedural fluid burden.</description><subject>Ablation</subject><subject>Arrhythmia</subject><subject>Blanking</subject><subject>Cardiology</subject><subject>Complications</subject><subject>Contact force</subject><subject>Feasibility studies</subject><subject>Fibrillation</subject><subject>Fluoroscopy</subject><subject>Intubation</subject><subject>Ischemia</subject><subject>Lavage</subject><subject>Medical instruments</subject><subject>Medical technology</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Pulmonary arteries</subject><subject>Radio frequency</subject><subject>Radiofrequency ablation</subject><subject>Reduction</subject><subject>Sensors</subject><subject>Tamponade</subject><subject>Technology</subject><subject>Transient ischemic attack</subject><issn>1861-0684</issn><issn>1861-0692</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kd1q3DAQhU1paNKkD9CbMtCb3rgdWfKPrkoJ_YNAc5FcG1ke7yp4NVtJTti36iNWm92mUCgIJEbfOTPSKYrXAt8LxPZDRJS6KlF0pahaLHfPijPRNaLERlfPn86dOi1exniHWAuU6kVxWulWYYt4Vvy6WRMMFBPwBOmB4YHDPMaPcL3MG_Ym7OCenAcXeTbJsYclOr8CA57vaYZgRsdToJ8LebsDMxwpa9KaEgVw3nLYcsjlLLPsk7EJJg6WIJJ_NEtk155nXmUDP0LdlGueCbKKlwjJbcGF4FaPzhfFyWTmSK-O-3lx--XzzeW38urH1--Xn65Kq2SXypYqa4dJ1CMSimGUZmymRpOWY90Oopu0zjWjlLFYSdKNVlONma_zqqmT58W7g-82cH5cTP3GRUvzbDzlqfoKZdN2XYcyo2__Qe94CT5Pt6dqrWSrVKbEgbKBYww09dvgNvmDe4H9Ps7-EGef4-z3cfa7rHlzdF6GDY1Pij_5ZaA6ADFf-RWFv63_7_obiaGvWg</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Maurer, Tilman</creator><creator>Rottner, Laura</creator><creator>Makimoto, Hisaki</creator><creator>Reissmann, Bruno</creator><creator>Heeger, Christian-H.</creator><creator>Lemes, Christine</creator><creator>Fink, Thomas</creator><creator>Riedl, Johannes</creator><creator>Santoro, Francesco</creator><creator>Wohlmuth, Peter</creator><creator>Volkmer, Marius</creator><creator>Mathew, Shibu</creator><creator>Metzner, Andreas</creator><creator>Ouyang, Feifan</creator><creator>Kuck, Karl-Heinz</creator><creator>Sohns, Christian</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20181101</creationdate><title>The best of two worlds? Pulmonary vein isolation using a novel radiofrequency ablation catheter incorporating contact force sensing technology and 56-hole porous tip irrigation</title><author>Maurer, Tilman ; Rottner, Laura ; Makimoto, Hisaki ; Reissmann, Bruno ; Heeger, Christian-H. ; Lemes, Christine ; Fink, Thomas ; Riedl, Johannes ; Santoro, Francesco ; Wohlmuth, Peter ; Volkmer, Marius ; Mathew, Shibu ; Metzner, Andreas ; Ouyang, Feifan ; Kuck, Karl-Heinz ; Sohns, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-7e2ccbf15d0e01bd3ad6f69e93d57b18f99d3aa44ac023e9694f50f1551555e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Ablation</topic><topic>Arrhythmia</topic><topic>Blanking</topic><topic>Cardiology</topic><topic>Complications</topic><topic>Contact force</topic><topic>Feasibility studies</topic><topic>Fibrillation</topic><topic>Fluoroscopy</topic><topic>Intubation</topic><topic>Ischemia</topic><topic>Lavage</topic><topic>Medical instruments</topic><topic>Medical technology</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Original Paper</topic><topic>Patients</topic><topic>Pulmonary arteries</topic><topic>Radio frequency</topic><topic>Radiofrequency ablation</topic><topic>Reduction</topic><topic>Sensors</topic><topic>Tamponade</topic><topic>Technology</topic><topic>Transient ischemic attack</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maurer, Tilman</creatorcontrib><creatorcontrib>Rottner, Laura</creatorcontrib><creatorcontrib>Makimoto, Hisaki</creatorcontrib><creatorcontrib>Reissmann, Bruno</creatorcontrib><creatorcontrib>Heeger, Christian-H.</creatorcontrib><creatorcontrib>Lemes, Christine</creatorcontrib><creatorcontrib>Fink, Thomas</creatorcontrib><creatorcontrib>Riedl, Johannes</creatorcontrib><creatorcontrib>Santoro, Francesco</creatorcontrib><creatorcontrib>Wohlmuth, Peter</creatorcontrib><creatorcontrib>Volkmer, Marius</creatorcontrib><creatorcontrib>Mathew, Shibu</creatorcontrib><creatorcontrib>Metzner, Andreas</creatorcontrib><creatorcontrib>Ouyang, Feifan</creatorcontrib><creatorcontrib>Kuck, Karl-Heinz</creatorcontrib><creatorcontrib>Sohns, Christian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical research in cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maurer, Tilman</au><au>Rottner, Laura</au><au>Makimoto, Hisaki</au><au>Reissmann, Bruno</au><au>Heeger, Christian-H.</au><au>Lemes, Christine</au><au>Fink, Thomas</au><au>Riedl, Johannes</au><au>Santoro, Francesco</au><au>Wohlmuth, Peter</au><au>Volkmer, Marius</au><au>Mathew, Shibu</au><au>Metzner, Andreas</au><au>Ouyang, Feifan</au><au>Kuck, Karl-Heinz</au><au>Sohns, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The best of two worlds? Pulmonary vein isolation using a novel radiofrequency ablation catheter incorporating contact force sensing technology and 56-hole porous tip irrigation</atitle><jtitle>Clinical research in cardiology</jtitle><stitle>Clin Res Cardiol</stitle><addtitle>Clin Res Cardiol</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>107</volume><issue>11</issue><spage>1003</spage><epage>1012</epage><pages>1003-1012</pages><issn>1861-0684</issn><eissn>1861-0692</eissn><abstract>Aims This study aimed to evaluate feasibility and safety as well as 1-year clinical outcome of pulmonary vein isolation (PVI) using a unique radiofrequency ablation catheter (“Thermocool SmartTouch SurroundFlow”; STSF) incorporating both, contact force (CF) sensing technology and enhanced tip irrigation with 56 holes, in one device. Methods A total of 110 patients suffering from drug-refractory atrial fibrillation underwent wide area circumferential PVI using either the STSF ablation catheter (75 consecutive patients, study group) or a CF catheter with conventional tip irrigation (“Thermocool SmartTouch”, 35 consecutive patients, control group). For each ablation lesion, a target CF of ≥ 10–39 g and a force time integral (FTI) of &gt; 400 g s was targeted. Results Acute PVI was achieved in all patients with target CF obtained in &gt; 85% of ablation points when using either device. Mean procedure time (131.3 ± 33.7 min in the study group vs. 133.0 ± 42.0 min in the control group; p  = 0.99), mean fluoroscopy time (14.0 ± 6 vs. 13.5 ± 6.6 min; p  = 0.56) and total ablation time were not significantly different (1751.0 ± 394.0 vs. 1604.6 ± 287.8 s; p  = 0.2). However, there was a marked reduction in total irrigation fluid delivery by 51.7% (265.52 ± 64.4 vs. 539.6 ± 118.2 ml; p  &lt; 0.01). The Kaplan–Meier estimate 12-month arrhythmia–free survival after the index procedure following a 3-month blanking period was 79.9% (95% CI 70.4%, 90.4%) for the study group and 66.7% for the control group (95% CI 50.2%, 88.5%). This finding did not reach statistical significance ( p  = 0.18). Major complications occurred in 2/75 patients (2.7%; one pericardial tamponade and one transient ischemic attack) in the study group and no patient in the control group ( p  = 18). Conclusion PVI using the STSF catheter is safe and effective and results in beneficial 1-year clinical outcome. The improved tip irrigation leads to a significant reduction in procedural fluid burden.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29740700</pmid><doi>10.1007/s00392-018-1270-y</doi><tpages>10</tpages></addata></record>
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subjects Ablation
Arrhythmia
Blanking
Cardiology
Complications
Contact force
Feasibility studies
Fibrillation
Fluoroscopy
Intubation
Ischemia
Lavage
Medical instruments
Medical technology
Medicine
Medicine & Public Health
Original Paper
Patients
Pulmonary arteries
Radio frequency
Radiofrequency ablation
Reduction
Sensors
Tamponade
Technology
Transient ischemic attack
title The best of two worlds? Pulmonary vein isolation using a novel radiofrequency ablation catheter incorporating contact force sensing technology and 56-hole porous tip irrigation
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