MicroRNAs and Cancer: Short RNAs Go a Long Way

MicroRNAs and Cancer: Short RNAs Go a Long Way

MicroRNAs (miRNAs) may be important regulators of gene expression. By modulating oncogenic and tumor suppressor pathways they could, in principle, contribute to tumorigenesis. Consistent with this hypothesis, recurrent genetic and epigenetic alterations of individual miRNAs are found in some tumors....

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Veröffentlicht in:Cell 2009-02, Vol.136 (4), p.586-591
Hauptverfasser: Ventura, Andrea, Jacks, Tyler
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Carcinogens
Epigenesis, Genetic
Genes, Tumor Suppressor
Humans
MicroRNAs - genetics
Neoplasms - genetics
RNA, Messenger
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Zusammenfassung:MicroRNAs (miRNAs) may be important regulators of gene expression. By modulating oncogenic and tumor suppressor pathways they could, in principle, contribute to tumorigenesis. Consistent with this hypothesis, recurrent genetic and epigenetic alterations of individual miRNAs are found in some tumors. Functional studies are now elucidating the mechanism of action of putative oncogenic and tumor suppressor miRNAs.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2009.02.005