Wireless optical monitoring system identifies limb induration characteristics in patients with Kawasaki disease

According to our results, relative HbT concentrations in the KD1 (0.6302 ± 0.004) and KD2 (0.6320 ± 0.002) groups were significantly lower than those in the HC group (0.6455 ± 0.002) and FC group (0.6416 ± 0.003, all P < .05); in the KD3 group values increased to within the same range as the control subjects (0.6429 ± 0.003, KD3 vs HC groups; P > .05). Total white blood cell count, hemoglobin level, platelet count, and albumin, liver enzyme, C-reactive protein, and segment/lymphocyte/eosinophil proportions from peripheral blood samples were also analyzed with data from the wireless optical monitoring system. Lower relative HbT concentrations in patients with KD suggest that palmar erythema might not be the result of increased hemoglobin levels because it can be explained by iron deficiency and hepcidin, which are common findings in patients with KD and are related to a longer duration of inflammation.8 The greater relative water concentrations found in the patients with KD compared with the control subjects is due to patients with KD presenting with angioedema, which is not a symptom in the FC group.9 Furthermore, the proposed optical device provides such advantages as noninvasive measurement and wireless transmission, both of which can substantially improve the convenience of use in clinical applications.