Effects of Folk Acid and Vitamin C on Arsenic Induced Mice

In this study, 5 weeks old mice weighing 22c2 g were grouped in four, each group consisting of six animals. Group-I, II, III and TV of the animals were fed by a standard diet quantity sufficient, normal diet with dissolved arsenic, arsenic with folic acid mixed and arsenic with vitamin C mixed, respectively. Blood was collected from the sacrificed animals and the blood glucose levels were determined by spectrophotometrically and glucometer. The average blood glucose level of arsenic induced animals was 9.37 mmol L super(-1) compared to 6.53 mmol L super(-1) in control animals whereas the blood glucose level of Group-III and Group-IV were 6.73 and 7.03 mmol L super(-1), respectively. Weight gain of the arsenic induced animals was lower compared to that of the animals fed with normal diet, folic acid mixed diet or vitamin C mixed diet. After sacrifice, the weight of kidney, heart and lung of arsenic induced animals were less than that of the Group-III and Group-IV. The reduction of arsenic induced higher blood glucose level by folic acid and vitamin C demonstrates that folic acid and vitamin C has significant effect in preventing arsenic induced disease.