Immune depression syndrome following human spinal cord injury (SCI): A pilot study

Abstract Experimental spinal cord injury (SCI) has been identified to trigger a systemic, neurogenic immune depression syndrome. Here, we have analyzed fluctuations of immune cell populations following human SCI by FACS analysis. In humans, a rapid and drastic decrease of CD14+ monocytes (

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2009-02, Vol.158 (3), p.1194-1199
Hauptverfasser:	Riegger, T, Conrad, S, Schluesener, H.J, Kaps, H.-P, Badke, A, Baron, C, Gerstein, J, Dietz, K, Abdizahdeh, M, Schwab, J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, Surface - immunology Biological and medical sciences Causality Female Flow Cytometry functional neurological recovery Fundamental and applied biological sciences. Psychology Humans Immune Tolerance - drug effects Immune Tolerance - immunology Immunity, Innate - drug effects Immunity, Innate - immunology Immunocompromised Host - drug effects Immunocompromised Host - immunology Immunologic Deficiency Syndromes - chemically induced Immunologic Deficiency Syndromes - immunology Immunologic Deficiency Syndromes - physiopathology Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects infections innate and adaptive immunity intrinsic recovery potential Lymphocyte Count Lymphopenia - chemically induced Lymphopenia - immunology Lymphopenia - physiopathology Male Methylprednisolone - administration & dosage Methylprednisolone - adverse effects Middle Aged mortality Neuroimmunomodulation - drug effects Neuroimmunomodulation - immunology Neurology Pilot Projects secondary immune deficiency Spinal Cord Injuries - complications Spinal Cord Injuries - drug therapy Spinal Cord Injuries - immunology Vertebrates: nervous system and sense organs Young Adult
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Beschreibung
Zusammenfassung:	Abstract Experimental spinal cord injury (SCI) has been identified to trigger a systemic, neurogenic immune depression syndrome. Here, we have analyzed fluctuations of immune cell populations following human SCI by FACS analysis. In humans, a rapid and drastic decrease of CD14+ monocytes (
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2008.08.021