Towards a durable RNAi gene therapy for HIV-AIDS

Towards a durable RNAi gene therapy for HIV-AIDS

Background: RNA interference (RNAi) can be employed as a potent antiviral mechanism Objective: To discuss RNAi approaches to target pathogenic human viruses causing acute or chronic infections, in particular RNAi gene therapy against HIV-1. Methods: A review of relevant literature. Results/conclusio...

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Veröffentlicht in:Expert opinion on biological therapy 2009-02, Vol.9 (2), p.161-170
Hauptverfasser: Berkhout, Ben, ter Brake, Olivier
Format: Artikel
Sprache:eng
Schlagworte:
antiviral
gene therapy
Genetic Therapy
Genetic Vectors
HIV Infections - therapy
HIV-1
HIV-1 - genetics
Human immunodeficiency virus 1
Humans
lentiviral vector
RNA Interference
RNAi
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Zusammenfassung:Background: RNA interference (RNAi) can be employed as a potent antiviral mechanism Objective: To discuss RNAi approaches to target pathogenic human viruses causing acute or chronic infections, in particular RNAi gene therapy against HIV-1. Methods: A review of relevant literature. Results/conclusions: The future of antiviral RNAi therapeutics is very promising. RNAi was discovered only a decade ago, and although we are still in the early days, the first clinical trials are already ongoing.
ISSN:1471-2598
1744-7682
DOI:10.1517/14712590802653619