Two new β-carboline alkaloids from the stems of Picrasma quassioides
Two new β -carboline alkaloids, 1-acetyl-4-methoxy-8-hydroxy- β -carboline ( 1 ) and 1-acetyl-4,8-dimethoxy- β -carboline ( 2 ), together with 10 known compounds; seven β -carboline alkaloids ( 3 – 9 ), two canthin-6-one alkaloids ( 10 and 11 ), and one quassinoid ( 12 ) were isolated from the stems...
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| Veröffentlicht in: | Archives of pharmacal research 2018-05, Vol.41 (5), p.513-518 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Two new
β
-carboline alkaloids, 1-acetyl-4-methoxy-8-hydroxy-
β
-carboline (
1
) and 1-acetyl-4,8-dimethoxy-
β
-carboline (
2
), together with 10 known compounds; seven
β
-carboline alkaloids (
3
–
9
), two canthin-6-one alkaloids (
10
and
11
), and one quassinoid (
12
) were isolated from the stems of
Picrasma quassioides
. The structure of the new compounds
1
and
2
were determined by spectroscopic analyses including 1D- and 2D-NMR and HRMS interpretation. All the isolates (
1
–
12
) were evaluated for their cytotoxicity against human ovarian carcinoma A2780 and SKOV3 cell lines using MTT assays. Of the isolates, compounds
5
–
7
exhibited the most potent cytotoxicity on both A2780 and SKOV3 cell lines
in vitro
. |
|---|---|
| ISSN: | 0253-6269 1976-3786 |
| DOI: | 10.1007/s12272-018-1034-2 |