Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors

Interleukin (IL)-27 is a multifunctional cytokine that belongs to the IL-6/IL-12 family and has potent antitumor activity through various mechanisms. Our novel findings indicate that IL-27 directly acts on hematopoietic stem cells and promotes their expansion and differentiation into myeloid progeni...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Oncoimmunology 2018-05, Vol.7 (5), p.e1421892-e1421892
Hauptverfasser:	Orii, Naoko, Mizoguchi, Izuru, Chiba, Yukino, Hasegawa, Hideaki, Ohashi, Mio, Xu, Mingli, Nagai, Taro, Ochiai, Nakaba, Mochizuki, Yuki, Owaki, Toshiyuki, Yoshimoto, Takayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	antitumor activity Author's View emergency myelopoiesis hematopoietic stem cells IL-27 myeloid progenitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!