Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors

Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors

Interleukin (IL)-27 is a multifunctional cytokine that belongs to the IL-6/IL-12 family and has potent antitumor activity through various mechanisms. Our novel findings indicate that IL-27 directly acts on hematopoietic stem cells and promotes their expansion and differentiation into myeloid progeni...

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Veröffentlicht in:Oncoimmunology 2018-05, Vol.7 (5), p.e1421892-e1421892
Hauptverfasser: Orii, Naoko, Mizoguchi, Izuru, Chiba, Yukino, Hasegawa, Hideaki, Ohashi, Mio, Xu, Mingli, Nagai, Taro, Ochiai, Nakaba, Mochizuki, Yuki, Owaki, Toshiyuki, Yoshimoto, Takayuki
Format: Artikel
Sprache:eng
Schlagworte:
antitumor activity
Author's View
emergency myelopoiesis
hematopoietic stem cells
IL-27
myeloid progenitors
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Beschreibung
Zusammenfassung:Interleukin (IL)-27 is a multifunctional cytokine that belongs to the IL-6/IL-12 family and has potent antitumor activity through various mechanisms. Our novel findings indicate that IL-27 directly acts on hematopoietic stem cells and promotes their expansion and differentiation into myeloid progenitors to control infection and to eradicate tumors.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.1080/2162402X.2017.1421892