Concomitant desalting and concentration of neuropeptides on a donut-shaped surface pattern for MALDI mass spectrometry

We demonstrate that a donut-shaped surface pattern consisting of a central hydrophobic region and a surrounding hydrophilic region simultaneously concentrates and desalts a solution of neuropeptides with a high salt content. Our approach greatly simplifies the sample preparation process for MALDI ma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2018, Vol.54 (45), p.5688-5691
Hauptverfasser:	Yoon, Sook, Park, Sanghwan, Kim, Min Sun, Lee, Chang Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin I - chemistry Bradykinin - analogs & derivatives Bradykinin - chemistry Corticotropin-Like Intermediate Lobe Peptide - chemistry Desalination Desorption Gold - chemistry Hydrophobic and Hydrophilic Interactions Ions Kinetics Limit of Detection Mass spectrometry Models, Chemical Neuropeptides Neuropeptides - chemistry Saline Waters - chemistry Scientific imaging Silicon - chemistry Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - instrumentation Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectroscopy Sulfhydryl Compounds - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We demonstrate that a donut-shaped surface pattern consisting of a central hydrophobic region and a surrounding hydrophilic region simultaneously concentrates and desalts a solution of neuropeptides with a high salt content. Our approach greatly simplifies the sample preparation process for MALDI mass spectrometry.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c8cc02168f