Recommendations to report and interpret HLA genetic findings in coeliac disease

Recommendations to report and interpret HLA genetic findings in coeliac disease

Coeliac disease (CD) is a chronic autoimmune enteropathy triggered by gluten and related prolamines in genetically predisposed individuals. Although CD is a polygenic disease, there is a strong association with genes of the human leukocyte antigen (HLA) region. Most patients present the HLA-DQ2 hete...

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Veröffentlicht in:Revista española de enfermedades digestivas 2018-07, Vol.110 (7), p.458-461
Hauptverfasser: Núñez, Concepción, Garrote, José Antonio, Arranz, Eduardo, Bilbao, José Ramón, Fernández Bañares, Fernando, Jiménez, Juana, Perucho, Teresa, Ruiz Casares, Eva, Sánchez-Valverde, Félix, Serrano, Juan I
Format: Artikel
Sprache:eng
Schlagworte:
Celiac Disease - diagnosis
Celiac Disease - genetics
Genetic Predisposition to Disease
HLA Antigens - genetics
Humans
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Beschreibung
Zusammenfassung:Coeliac disease (CD) is a chronic autoimmune enteropathy triggered by gluten and related prolamines in genetically predisposed individuals. Although CD is a polygenic disease, there is a strong association with genes of the human leukocyte antigen (HLA) region. Most patients present the HLA-DQ2 heterodimer, specifically the DQ2.5 isoform, which is present in around 90-96% of patients of European ancestry.
ISSN:1130-0108
DOI:10.17235/reed.2018.5269/2017