Towards the Development of Antitumor Vaccines: A Synthetic Conjugate of a Tumor-Associated MUC1 Glycopeptide Antigen and a Tetanus Toxin Epitope

Towards the Development of Antitumor Vaccines: A Synthetic Conjugate of a Tumor-Associated MUC1 Glycopeptide Antigen and a Tetanus Toxin Epitope

Proliferation of cytotoxic T‐cells, a prerequisite for the development of antitumor vaccines, was induced by 1, but not by its partial structures A and B. The conjugate 1 containing a tumor‐associated Sialyl–TN–MUC‐1 glycopeptide antigen A and a T‐cell epitope B of tetanus toxin was synthesized by f...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2001-01, Vol.40 (2), p.366-369
Hauptverfasser: Keil, Stefanie, Claus, Christine, Dippold, Wolfgang, Kunz, Horst
Format: Artikel
Sprache:eng
Schlagworte:
antigens
antitumor agents
glycopeptides
solid-phase synthesis
vaccines
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Proliferation of cytotoxic T‐cells, a prerequisite for the development of antitumor vaccines, was induced by 1, but not by its partial structures A and B. The conjugate 1 containing a tumor‐associated Sialyl–TN–MUC‐1 glycopeptide antigen A and a T‐cell epitope B of tetanus toxin was synthesized by fragment condensation on a solid phase.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20010119)40:2<366::AID-ANIE366>3.0.CO;2-J