Enantioselective Incorporation of Azobenzenes into Oligodeoxyribonucleotide for Effective Photoregulation of Duplex Formation

Enantioselective Incorporation of Azobenzenes into Oligodeoxyribonucleotide for Effective Photoregulation of Duplex Formation

A drop in melting point of 21.5°C is induced by the UV‐photolytic trans→cis isomerization of the duplex formed between an oligonucleotide bearing two D‐threoninol‐tethered azobenzene moieties (see picture) in the side chain and its complementary counterpart. On irradiation with visible light, the di...

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Veröffentlicht in:Angewandte Chemie International Edition 2001-07, Vol.40 (14), p.2671-2673
Hauptverfasser: Asanuma, Hiroyuki, Takarada, Tohru, Yoshida, Takayuki, Tamaru, Daisuke, Liang, Xingguo, Komiyama, Makoto
Format: Artikel
Sprache:eng
Schlagworte:
azo compounds
DNA structures
isomerization
nucleotides
photochemistry
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Zusammenfassung:A drop in melting point of 21.5°C is induced by the UV‐photolytic trans→cis isomerization of the duplex formed between an oligonucleotide bearing two D‐threoninol‐tethered azobenzene moieties (see picture) in the side chain and its complementary counterpart. On irradiation with visible light, the dissociated single‐stranded oligonucleotides regenerate the duplex.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20010716)40:14<2671::AID-ANIE2671>3.0.CO;2-Z