Tissue-selective alteration of ethanolamine plasmalogen metabolism in dedifferentiated colon mucosa

Human colon lipid analysis by imaging mass spectrometry (IMS) demonstrates that the lipid fingerprint is highly sensitive to a cell's pathophysiological state. Along the colon crypt axis, and concomitant to the differentiation process, certain lipid species tightly linked to signaling (phosphat...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular and cell biology of lipids 2018-08, Vol.1863 (8), p.928-938
Hauptverfasser:	Lopez, Daniel H., Bestard-Escalas, Joan, Garate, Jone, Maimó-Barceló, Albert, Fernández, Roberto, Reigada, Rebeca, Khorrami, Sam, Ginard, Daniel, Okazaki, Toshiro, Fernández, José A., Barceló-Coblijn, Gwendolyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Adenomatous Polyps - pathology Adult Aged Biopsy Cell Dedifferentiation - physiology Colon - cytology Colon - pathology Colon - physiology Colonic Neoplasms - pathology Colonocyte differentiation Colonoscopy Colorectal cancer Epithelial Cells - pathology Epithelial Cells - physiology Ethanolamine ether lipids Female Healthy Volunteers Humans Imaging mass spectrometry Intestinal Mucosa - cytology Intestinal Mucosa - pathology Intestinal Mucosa - physiology Lipid Metabolism - physiology Lipidomics MALDI-imaging Male Middle Aged Plasmalogens Plasmalogens - analysis Plasmalogens - metabolism
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