α(1-3)-Galactosyltransferase Inhibition Based on a New Type of Disubstrate Analogue

α(1-3)-Galactosyltransferase Inhibition Based on a New Type of Disubstrate Analogue

How do retaining glycosyltransferases function? To answer this question, UDP‐Gal and galactose were covalently linked to form disubstrate analogues 1, of which surprisingly 1β and not 1α inhibited α(1‐3)‐galactosyltransferases very well. An understanding of this inhibition is a key to the pharmacolo...

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Veröffentlicht in:Angewandte Chemie International Edition 2001-11, Vol.40 (21), p.4007-4011
Hauptverfasser: Waldscheck, Bernhard, Streiff, Markus, Notz, Wolfgang, Kinzy, Willy, Schmidt, Richard R.
Format: Artikel
Sprache:eng
Schlagworte:
C-glycosides
C-ketosides
disubstrate analogues
inhibitors
transferases
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Zusammenfassung:How do retaining glycosyltransferases function? To answer this question, UDP‐Gal and galactose were covalently linked to form disubstrate analogues 1, of which surprisingly 1β and not 1α inhibited α(1‐3)‐galactosyltransferases very well. An understanding of this inhibition is a key to the pharmacological prevention of hyperacute rejection in pig to primate xenotransplantation.
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20011105)40:21<4007::AID-ANIE4007>3.0.CO;2-F