Long-Range Electron Transfer through DNA Films

Regardless of its position within the DNA film, cross‐linked daunomycin (DM) is efficiently reduced electrochemically, indicating that the electron transfer exhibits a shallow distance dependence. Upon the introduction of an intervening cytosine–adenine (CA) mismatch, the electrochemical response is...

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Veröffentlicht in:	Angewandte Chemie International Edition 1999-04, Vol.38 (7), p.941-945
Hauptverfasser:	Kelley, Shana O., Jackson, Nicole M., Hill, Michael G., Barton, Jacqueline K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosensors Cyclic voltammetry DNA structures Electron transfer Monolayers Thin films
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description	Regardless of its position within the DNA film, cross‐linked daunomycin (DM) is efficiently reduced electrochemically, indicating that the electron transfer exhibits a shallow distance dependence. Upon the introduction of an intervening cytosine–adenine (CA) mismatch, the electrochemical response is dramatically attenuated (shown schematically). Therefore, the DNA double helix can facilitate long‐range electron transfer, but only in the presence of a well‐stacked pathway.
doi_str_mv	10.1002/(SICI)1521-3773(19990401)38:7<941::AID-ANIE941>3.0.CO;2-7
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subjects	Biosensors Cyclic voltammetry DNA structures Electron transfer Monolayers Thin films
title	Long-Range Electron Transfer through DNA Films
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